Dipole source localization in the study of EP generators: a critique

Abraham Z. Snyder

doi:10.1016/0168-5597(91)90116-F

Dipole source localization in the study of EP generators: a critique

Abraham Z. Snyder

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Abstract

1. (1) The decision to solve the inverse problem in terms of one or more localized generators implies the assumption of a particular generator model. This assumption permits carrying out inverse dipole estimation. However, it is perilous to justify the procedure on the basis of the result. 2. (2) Goodness of fit is a necessary but not sufficient criterion of model adequacy. A particular quantitative inverse solution has meaning only if it is accompanied by consideration of sensitivity to small changes in all of the free modeling parameters and estimates of perturbing factors including noise and forward calculation uncertainties.

Original language	English
Pages (from-to)	321-325
Number of pages	5
Journal	Electroencephalography and Clinical Neurophysiology/ Evoked Potentials
Volume	80
Issue number	4
DOIs	https://doi.org/10.1016/0168-5597(91)90116-F
State	Published - 1991

Keywords

Dipole source localization
EP generator

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10.1016/0168-5597(91)90116-F

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title = "Dipole source localization in the study of EP generators: a critique",

abstract = "1. (1) The decision to solve the inverse problem in terms of one or more localized generators implies the assumption of a particular generator model. This assumption permits carrying out inverse dipole estimation. However, it is perilous to justify the procedure on the basis of the result. 2. (2) Goodness of fit is a necessary but not sufficient criterion of model adequacy. A particular quantitative inverse solution has meaning only if it is accompanied by consideration of sensitivity to small changes in all of the free modeling parameters and estimates of perturbing factors including noise and forward calculation uncertainties.",

keywords = "Dipole source localization, EP generator",

author = "Snyder, {Abraham Z.}",

note = "Funding Information: Supported by NIH Grant NS06833 and the McDonnell Center for Studies of Higher Brain Function.",

year = "1991",

doi = "10.1016/0168-5597(91)90116-F",

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N1 - Funding Information: Supported by NIH Grant NS06833 and the McDonnell Center for Studies of Higher Brain Function.

PY - 1991

Y1 - 1991

N2 - 1. (1) The decision to solve the inverse problem in terms of one or more localized generators implies the assumption of a particular generator model. This assumption permits carrying out inverse dipole estimation. However, it is perilous to justify the procedure on the basis of the result. 2. (2) Goodness of fit is a necessary but not sufficient criterion of model adequacy. A particular quantitative inverse solution has meaning only if it is accompanied by consideration of sensitivity to small changes in all of the free modeling parameters and estimates of perturbing factors including noise and forward calculation uncertainties.

AB - 1. (1) The decision to solve the inverse problem in terms of one or more localized generators implies the assumption of a particular generator model. This assumption permits carrying out inverse dipole estimation. However, it is perilous to justify the procedure on the basis of the result. 2. (2) Goodness of fit is a necessary but not sufficient criterion of model adequacy. A particular quantitative inverse solution has meaning only if it is accompanied by consideration of sensitivity to small changes in all of the free modeling parameters and estimates of perturbing factors including noise and forward calculation uncertainties.

KW - Dipole source localization

KW - EP generator

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U2 - 10.1016/0168-5597(91)90116-F

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JO - Electroencephalography and Clinical Neurophysiology/ Evoked Potentials

JF - Electroencephalography and Clinical Neurophysiology/ Evoked Potentials

IS - 4

ER -

Dipole source localization in the study of EP generators: a critique

Abstract

Keywords

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