Diminution of bone mass in childhood diabetes

A. L. Rosenbloom, D. C. Lezotte, F. T. Weber, J. Gudat, D. R. Heller, M. L. Weber, S. Klein, B. B. Kennedy

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Photon absorption measurements of forearm bone density in 196 insulin-dependent patients, age 6-26 years, were compared with findings in 124 controls. Expected density, gm Ca/cm2 bone width (M/W), was calculated from regressions of M/W on ulnar length for white and black male and female controls. There were no significant correlations between M/W differences from expected and serum Ca, Mg, P, or alkaline phosphatase levels, estimated physical activity level, insulin dosage, or the presence of joint contracture. White females averaged 8.2% (± 1 S.E.M.) loss of M/W, as against white male average loss of 4.7% ± 1 and black female loss of 2% ± 2 (p < 0.001); the black male population was too small for separate analysis. M/W loss > 10% was seen in 29% of white males, 19% of blacks, and 48% of white females (p < 0.02). When the groups were further divided into those with duration of diabetes ≤ five years and those with duration > five years, significant reduction in M/W average loss over time was seen with white females (10.6% ± 1.2 to 3.7% ± 1.5, p < 0.0001). Expression of this defect in bone mineralization is controlled by race and sex acting independently of each other.

Original languageEnglish
Pages (from-to)1052-1055
Number of pages4
JournalUnknown Journal
Issue number11
StatePublished - Jan 1 1977

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    Rosenbloom, A. L., Lezotte, D. C., Weber, F. T., Gudat, J., Heller, D. R., Weber, M. L., Klein, S., & Kennedy, B. B. (1977). Diminution of bone mass in childhood diabetes. Unknown Journal, 26(11), 1052-1055. https://doi.org/10.2337/diab.26.11.1052