Diminished cortical thickness is associated with impulsive choice in adolescence

Marieta Pehlivanova, Daniel H. Wolf, Aristeidis Sotiras, Antonia N. Kaczkurkin, Tyler M. Moore, Rastko Ciric, Philip A. Cook, Angel Garcia de la Garza, Adon F.G. Rosen, Kosha Ruparel, Anup Sharma, Russell T. Shinohara, David R. Roalf, Ruben C. Gur, Christos Davatzikos, Raquel E. Gur, Joseph W. Kable, Theodore D. Satterthwaite

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Adolescence is characterized by both maturation of brain structure and increased risk of negative outcomes from behaviors associated with impulsive decision-making. One important index of impulsive choice is delay discounting (DD), which measures the tendency to prefer smaller rewards available soon over larger rewards delivered after a delay. However, it remains largely unknown how individual differences in structural brain development may be associated with impulsive choice during adolescence. Leveraging a unique large sample of 427 human youths (208 males and 219 females) imaged as part of the Philadelphia Neurodevelopmental Cohort, we examined associations between delay discounting and cortical thickness within structural covariance networks. These structural networks were derived using non-negative matrix factorization, an advanced multivariate technique for dimensionality reduction, and analyzed using generalized additive models with penalized splines to capture both linear and nonlinear developmental effects. We found that impulsive choice, as measured by greater discounting, was most strongly associated with diminished cortical thickness in structural brain networks that encompassed the ventromedial prefrontal cortex, orbito frontal cortex, temporal pole, and temporoparietal junction. Furthermore, structural brain networks predicted DD above and beyond cognitive performance. Together, these results suggest that reduced cortical thickness in regions known to be involved in value-based decision-making is a marker of impulsive choice during the critical period of adolescence.

Original languageEnglish
Pages (from-to)2471-2481
Number of pages11
JournalJournal of Neuroscience
Volume38
Issue number10
DOIs
StatePublished - Mar 7 2018
Externally publishedYes

Keywords

  • Adolescence
  • Delay discounting
  • Development
  • Impulsivity
  • Networks
  • Neuroimaging

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    Pehlivanova, M., Wolf, D. H., Sotiras, A., Kaczkurkin, A. N., Moore, T. M., Ciric, R., Cook, P. A., de la Garza, A. G., Rosen, A. F. G., Ruparel, K., Sharma, A., Shinohara, R. T., Roalf, D. R., Gur, R. C., Davatzikos, C., Gur, R. E., Kable, J. W., & Satterthwaite, T. D. (2018). Diminished cortical thickness is associated with impulsive choice in adolescence. Journal of Neuroscience, 38(10), 2471-2481. https://doi.org/10.1523/JNEUROSCI.2200-17.2018