TY - JOUR
T1 - Diminished cortical thickness is associated with impulsive choice in adolescence
AU - Pehlivanova, Marieta
AU - Wolf, Daniel H.
AU - Sotiras, Aristeidis
AU - Kaczkurkin, Antonia N.
AU - Moore, Tyler M.
AU - Ciric, Rastko
AU - Cook, Philip A.
AU - de la Garza, Angel Garcia
AU - Rosen, Adon F.G.
AU - Ruparel, Kosha
AU - Sharma, Anup
AU - Shinohara, Russell T.
AU - Roalf, David R.
AU - Gur, Ruben C.
AU - Davatzikos, Christos
AU - Gur, Raquel E.
AU - Kable, Joseph W.
AU - Satterthwaite, Theodore D.
N1 - Funding Information:
This work was supported by Grants from the National Institute of Mental Health R01MH107703 (T.D.S.); NIMH RC2 Grants MH089983 and MH089924 (R.E.G.) for PNC; MH098899 and DA029149 (J.W.K.), K01MH102609 (D.R.R.), R01MH101111 (D.H.W.), R01-AG014971 and RF1-AG054409 (C.D., A.S.), P50MH096891 (R.E.G.), R01NS085211 (R.T.S.), and R01MH107235 (R.C.G.); the Dowshen Program for Neuroscience, and the Lifespan Brain Institute at the Children’s Hospital of Philadelphia and Penn Medicine; Seed Grant support by the Center for Biomedical Computing and Image Analysis (CBICA) for developing statistical analyses (R.T.S., T.D.S.) and non-negative matrix factorization software (A.S., T.D.S.); and Grants P50 AG05681, P01 AG03991, R01 AG021910, P20 MH071616, and U24 RR021382 for images from the OASIS project. We thank the acquisition and recruitment team including Karthik Prabhakaran and Jeff Valdez, Chad Jackson for data management and systems support, and Monica Calkins for phenotyping expertise.
Funding Information:
This work was supported by Grants from the National Institute of Mental Health R01MH107703 (T.D.S.); NIMH RC2GrantsMH089983andMH089924(R.E.G.)forPNC;MH098899andDA029149(J.W.K.),K01MH102609(D.R.R.), R01MH101111 (D.H.W.), R01-AG014971 and RF1-AG054409 (C.D., A.S.), P50MH096891 (R.E.G.), R01NS085211 (R.T.S.),andR01MH107235(R.C.G.);theDowshenProgramforNeuroscience,andtheLifespanBrainInstituteatthe Children’sHospitalofPhiladelphiaandPennMedicine;SeedGrantsupportbytheCenterforBiomedicalComputing
Publisher Copyright:
© 2018 the authors.
PY - 2018/3/7
Y1 - 2018/3/7
N2 - Adolescence is characterized by both maturation of brain structure and increased risk of negative outcomes from behaviors associated with impulsive decision-making. One important index of impulsive choice is delay discounting (DD), which measures the tendency to prefer smaller rewards available soon over larger rewards delivered after a delay. However, it remains largely unknown how individual differences in structural brain development may be associated with impulsive choice during adolescence. Leveraging a unique large sample of 427 human youths (208 males and 219 females) imaged as part of the Philadelphia Neurodevelopmental Cohort, we examined associations between delay discounting and cortical thickness within structural covariance networks. These structural networks were derived using non-negative matrix factorization, an advanced multivariate technique for dimensionality reduction, and analyzed using generalized additive models with penalized splines to capture both linear and nonlinear developmental effects. We found that impulsive choice, as measured by greater discounting, was most strongly associated with diminished cortical thickness in structural brain networks that encompassed the ventromedial prefrontal cortex, orbito frontal cortex, temporal pole, and temporoparietal junction. Furthermore, structural brain networks predicted DD above and beyond cognitive performance. Together, these results suggest that reduced cortical thickness in regions known to be involved in value-based decision-making is a marker of impulsive choice during the critical period of adolescence.
AB - Adolescence is characterized by both maturation of brain structure and increased risk of negative outcomes from behaviors associated with impulsive decision-making. One important index of impulsive choice is delay discounting (DD), which measures the tendency to prefer smaller rewards available soon over larger rewards delivered after a delay. However, it remains largely unknown how individual differences in structural brain development may be associated with impulsive choice during adolescence. Leveraging a unique large sample of 427 human youths (208 males and 219 females) imaged as part of the Philadelphia Neurodevelopmental Cohort, we examined associations between delay discounting and cortical thickness within structural covariance networks. These structural networks were derived using non-negative matrix factorization, an advanced multivariate technique for dimensionality reduction, and analyzed using generalized additive models with penalized splines to capture both linear and nonlinear developmental effects. We found that impulsive choice, as measured by greater discounting, was most strongly associated with diminished cortical thickness in structural brain networks that encompassed the ventromedial prefrontal cortex, orbito frontal cortex, temporal pole, and temporoparietal junction. Furthermore, structural brain networks predicted DD above and beyond cognitive performance. Together, these results suggest that reduced cortical thickness in regions known to be involved in value-based decision-making is a marker of impulsive choice during the critical period of adolescence.
KW - Adolescence
KW - Delay discounting
KW - Development
KW - Impulsivity
KW - Networks
KW - Neuroimaging
UR - http://www.scopus.com/inward/record.url?scp=85043373851&partnerID=8YFLogxK
U2 - 10.1523/JNEUROSCI.2200-17.2018
DO - 10.1523/JNEUROSCI.2200-17.2018
M3 - Article
C2 - 29440536
AN - SCOPUS:85043373851
SN - 0270-6474
VL - 38
SP - 2471
EP - 2481
JO - Journal of Neuroscience
JF - Journal of Neuroscience
IS - 10
ER -