Abstract
Calcium channel blockers are being used increasingly for a variety of cardiovascular problems. Diltiazem hydrochloride, a benzothiazepine derivative, has been reported to have a low incidence of adverse side effects. We report a case of acute psychosis associated with the use of diltiazem in a patient receiving lithium carbonate therapy. Both diltiazem hydrochloride and lithium carbonate have calcium antagonist effects in the central nervous system, and we review their mechanisms of action. A possible synergistic drug interaction between diltiazem and lithium is reported.
Original language | English |
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Pages (from-to) | 373-374 |
Number of pages | 2 |
Journal | Archives of internal medicine |
Volume | 151 |
Issue number | 2 |
DOIs | |
State | Published - Feb 1991 |