Abstract
Calcium channel blockers are being used increasingly for a variety of cardiovascular problems. Diltiazem hydrochloride, a benzothiazepine derivative, has been reported to have a low incidence of adverse side effects. We report a case of acute psychosis associated with the use of diltiazem in a patient receiving lithium carbonate therapy. Both diltiazem hydrochloride and lithium carbonate have calcium antagonist effects in the central nervous system, and we review their mechanisms of action. A possible synergistic drug interaction between diltiazem and lithium is reported.
| Original language | English |
|---|---|
| Pages (from-to) | 373-374 |
| Number of pages | 2 |
| Journal | Archives of internal medicine |
| Volume | 151 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 1991 |
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Binder, E. F., Cayabyab, L., Ritchie, D. J., & Birge, S. J. (1991). Diltiazem-Induced Psychosis and a Possible Diltiazem-Lithium Interaction. Archives of internal medicine, 151(2), 373-374. https://doi.org/10.1001/archinte.1991.00400020119023