Diltiazem-Induced Psychosis and a Possible Diltiazem-Lithium Interaction

Ellen F. Binder, Lillibeth Cayabyab, David J. Ritchie, Stanley J. Birge

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Calcium channel blockers are being used increasingly for a variety of cardiovascular problems. Diltiazem hydrochloride, a benzothiazepine derivative, has been reported to have a low incidence of adverse side effects. We report a case of acute psychosis associated with the use of diltiazem in a patient receiving lithium carbonate therapy. Both diltiazem hydrochloride and lithium carbonate have calcium antagonist effects in the central nervous system, and we review their mechanisms of action. A possible synergistic drug interaction between diltiazem and lithium is reported.

Original languageEnglish
Pages (from-to)373-374
Number of pages2
JournalArchives of internal medicine
Issue number2
StatePublished - Feb 1991


Dive into the research topics of 'Diltiazem-Induced Psychosis and a Possible Diltiazem-Lithium Interaction'. Together they form a unique fingerprint.

Cite this