Diltiazem-Induced Psychosis and a Possible Diltiazem-Lithium Interaction

Ellen F. Binder; Lillibeth Cayabyab; David J. Ritchie; Stanley J. Birge

doi:10.1001/archinte.1991.00400020119023

Diltiazem-Induced Psychosis and a Possible Diltiazem-Lithium Interaction

Ellen F. Binder, Lillibeth Cayabyab, David J. Ritchie, Stanley J. Birge

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Abstract

Calcium channel blockers are being used increasingly for a variety of cardiovascular problems. Diltiazem hydrochloride, a benzothiazepine derivative, has been reported to have a low incidence of adverse side effects. We report a case of acute psychosis associated with the use of diltiazem in a patient receiving lithium carbonate therapy. Both diltiazem hydrochloride and lithium carbonate have calcium antagonist effects in the central nervous system, and we review their mechanisms of action. A possible synergistic drug interaction between diltiazem and lithium is reported.

Original language	English
Pages (from-to)	373-374
Number of pages	2
Journal	Archives of internal medicine
Volume	151
Issue number	2
DOIs	https://doi.org/10.1001/archinte.1991.00400020119023
State	Published - Feb 1991

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Diltiazem-Induced Psychosis and a Possible Diltiazem-Lithium Interaction

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