Diffusion tensor imaging of normal-appearing white matter as biomarker for radiation-induced late delayed cognitive decline

Christopher H. Chapman, Vijaya Nagesh, Pia C. Sundgren, Henry Buchtel, Thomas L. Chenevert, Larry Junck, Theodore S. Lawrence, Christina I. Tsien, Yue Cao

Research output: Contribution to journalArticle

60 Scopus citations

Abstract

Purpose: To determine whether early assessment of cerebral white matter degradation can predict late delayed cognitive decline after radiotherapy (RT). Methods and Materials: Ten patients undergoing conformal fractionated brain RT participated in a prospective diffusion tensor magnetic resonance imaging study. Magnetic resonance imaging studies were acquired before RT, at 3 and 6 weeks during RT, and 10, 30, and 78 weeks after starting RT. The diffusivity variables in the parahippocampal cingulum bundle and temporal lobe white matter were computed. A quality-of-life survey and neurocognitive function tests were administered before and after RT at the magnetic resonance imaging follow-up visits. Results: In both structures, longitudinal diffusivity (λ ) decreased and perpendicular diffusivity (λ ) increased after RT, with early changes correlating to later changes (p < .05). The radiation dose correlated with an increase in cingulum λ at 3 weeks, and patients with >50% of cingula volume receiving >12 Gy had a greater increase in λ at 3 and 6 weeks (p < .05). The post-RT changes in verbal recall scores correlated linearly with the late changes in cingulum λ (30 weeks, p < .02). Using receiver operating characteristic curves, early cingulum λ changes predicted for post-RT changes in verbal recall scores (3 and 6 weeks, p < .05). The neurocognitive test scores correlated significantly with the quality-of-life survey results. Conclusions: The correlation between early diffusivity changes in the parahippocampal cingulum and the late decline in verbal recall suggests that diffusion tensor imaging might be useful as a biomarker for predicting late delayed cognitive decline.

Original languageEnglish
Pages (from-to)2033-2040
Number of pages8
JournalInternational Journal of Radiation Oncology Biology Physics
Volume82
Issue number5
DOIs
StatePublished - Apr 1 2012

Keywords

  • Biomarker
  • Diffusion tensor imaging
  • Late-delayed effects
  • Neurocognitive function
  • Quality of life

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    Chapman, C. H., Nagesh, V., Sundgren, P. C., Buchtel, H., Chenevert, T. L., Junck, L., Lawrence, T. S., Tsien, C. I., & Cao, Y. (2012). Diffusion tensor imaging of normal-appearing white matter as biomarker for radiation-induced late delayed cognitive decline. International Journal of Radiation Oncology Biology Physics, 82(5), 2033-2040. https://doi.org/10.1016/j.ijrobp.2011.01.068