Diffusion tensor imaging detects age-dependent white matter changes in a transgenic mouse model with amyloid deposition

Sheng Kwei Song, Joong Hee Kim, Shiow Jiuan Lin, Robert P. Brendza, David M. Holtzman

Research output: Contribution to journalArticlepeer-review

153 Scopus citations

Abstract

Increasing evidence demonstrates that there is marked damage and dysfunction not only in the gray matter but also in the white matter in Alzheimer's disease (AD). In this study, transgenic mice overexpressing β-amyloid precursor protein (APP) under control of the platelet-derived growth factor promoter (PDAPP mice) were examined using diffusion tensor magnetic resonance imaging (DTI) to evaluate the extent of white matter injury before and following the development of AD-like pathology. The profile of DTI parameters was significantly different in old PDAPP mice compared to that of old control mice following the development of AD-like pathology. No difference in DTI parameters was observed between the young PDAPP and control mice. Our results suggest that as amyloid β (Aβ) deposition and levels increase over time in PDAPP mice, these changes lead to primary or secondary white matter injury that can be detected by DTI.

Original languageEnglish
Pages (from-to)640-647
Number of pages8
JournalNeurobiology of Disease
Volume15
Issue number3
DOIs
StatePublished - Apr 2004

Keywords

  • Alzheimer's disease
  • Axon
  • Diffusion tensor
  • MRI
  • Mice
  • Myelin
  • PDAPP
  • White matter

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