TY - JOUR
T1 - Diffusion kurtosis MRI versus conventional diffusion-weighted imaging for evaluating inflammatory activity in Crohn's disease
AU - Huang, Li
AU - Li, Xue Hua
AU - Huang, Si Yun
AU - Zhang, Zhong Wei
AU - Yang, Xu Feng
AU - Lin, Jin Jiang
AU - Jiang, Meng Jie
AU - Feng, Shi Ting
AU - Sun, Can Hui
AU - Li, Zi Ping
N1 - Funding Information:
Contract grant sponsor: National Natural Science Foundation of China; contract grant number: 81600508 (PI: X.-h.L.); Contract grant sponsor: Science and Technology Planning Project of Guangdong Province; contract grant number: 2014A020212480 (PI: C.-h.S.). We thank Dr. Margaret H. Pui (Conde de S. Januario Central Hospital in Macau) for valuable suggestions. We also thank Dr. Xu Yan (Siemens Healthcare) for support of the project.
Publisher Copyright:
© 2017 International Society for Magnetic Resonance in Medicine
PY - 2018/3
Y1 - 2018/3
N2 - Purpose: To assess the efficacy of diffusion kurtosis imaging (DKI) and to compare DKI-derived parameters with that of conventional diffusion-weighted imaging (DWI) for grading the inflammatory activity of Crohn's disease (CD). Materials and Methods: In all, 38 patients with CD underwent 3T magnetic resonance enterography (MRE) with DKI (b values of 0–2000 s/mm 2 ). The inflammatory activity of the bowel segments was graded by magnetic resonance index of activity (MaRIA) as inactive (<7), mild (≥7 and <11), or moderate-severe (≥11). Apparent diffusion for non-Gaussian distribution (D app ) and apparent kurtosis coefficient (K app ) on DKI as well as apparent diffusion coefficient (ADC) on DWI were compared. Results: In all, 86 bowel segments including inactive (20), mild (19), and moderate-severe (47) CD were analyzed. The differences in K app , D app , and ADC among inactive, mild, and moderate-severe CD were significant (all P < 0.05). K app (r = 0.862), D app (r = −0.755), and ADC (r = −0.713) correlated well with MaRIA in all segments. Stronger correlation with MaRIA in moderate-severe CD was found for K app (r = 0.647) than that of D app (r = −0.414) and ADC (r = −0.580). Receiver operating characteristic (ROC) curve analysis showed high accuracy of K app , D app , and ADC for differentiating active from inactive CD (AUC: 0.953 for K app , 0.944 for D app , 0.907 for ADC) as well as differentiating inactive-mild from moderate-severe CD (AUC: 0.946 for K app , 0.887 for D app , 0.846 for ADC). The threshold K app of 0.731 allowed differentiation of active from inactive CD with 89.4% sensitivity and 95% specificity. Conclusion: DKI of CD is clinically feasible and might be superior to conventional DWI for grading the inflammatory activity of CD. Level of Evidence: 2. Technical Efficacy: Stage 2. J. Magn. Reson. Imaging 2018;47:702–709.
AB - Purpose: To assess the efficacy of diffusion kurtosis imaging (DKI) and to compare DKI-derived parameters with that of conventional diffusion-weighted imaging (DWI) for grading the inflammatory activity of Crohn's disease (CD). Materials and Methods: In all, 38 patients with CD underwent 3T magnetic resonance enterography (MRE) with DKI (b values of 0–2000 s/mm 2 ). The inflammatory activity of the bowel segments was graded by magnetic resonance index of activity (MaRIA) as inactive (<7), mild (≥7 and <11), or moderate-severe (≥11). Apparent diffusion for non-Gaussian distribution (D app ) and apparent kurtosis coefficient (K app ) on DKI as well as apparent diffusion coefficient (ADC) on DWI were compared. Results: In all, 86 bowel segments including inactive (20), mild (19), and moderate-severe (47) CD were analyzed. The differences in K app , D app , and ADC among inactive, mild, and moderate-severe CD were significant (all P < 0.05). K app (r = 0.862), D app (r = −0.755), and ADC (r = −0.713) correlated well with MaRIA in all segments. Stronger correlation with MaRIA in moderate-severe CD was found for K app (r = 0.647) than that of D app (r = −0.414) and ADC (r = −0.580). Receiver operating characteristic (ROC) curve analysis showed high accuracy of K app , D app , and ADC for differentiating active from inactive CD (AUC: 0.953 for K app , 0.944 for D app , 0.907 for ADC) as well as differentiating inactive-mild from moderate-severe CD (AUC: 0.946 for K app , 0.887 for D app , 0.846 for ADC). The threshold K app of 0.731 allowed differentiation of active from inactive CD with 89.4% sensitivity and 95% specificity. Conclusion: DKI of CD is clinically feasible and might be superior to conventional DWI for grading the inflammatory activity of CD. Level of Evidence: 2. Technical Efficacy: Stage 2. J. Magn. Reson. Imaging 2018;47:702–709.
KW - Crohn's disease
KW - diffusion kurtosis imaging
KW - diffusion-weighted imaging
KW - magnetic resonance index of activity
UR - http://www.scopus.com/inward/record.url?scp=85020112143&partnerID=8YFLogxK
U2 - 10.1002/jmri.25768
DO - 10.1002/jmri.25768
M3 - Article
C2 - 28577319
AN - SCOPUS:85020112143
SN - 1053-1807
VL - 47
SP - 702
EP - 709
JO - Journal of Magnetic Resonance Imaging
JF - Journal of Magnetic Resonance Imaging
IS - 3
ER -