TY - JOUR
T1 - Diffusion effects on longitudinal relaxation in poorly mixed compartments
AU - Anderson, J. R.
AU - Ye, Q.
AU - Neil, J. J.
AU - Ackerman, J. J.H.
AU - Garbow, J. R.
N1 - Funding Information:
Support from NIH grants T90 DA22871 , R01 EB002083 , P30 CA91842 , S10 RR022658 , and S10 RR020916 is gratefully acknowledged.
PY - 2011/7
Y1 - 2011/7
N2 - Diffusion of spins between physical or virtual, communicating compartments having different states of longitudinal magnetization leads to diffusion-driven longitudinal relaxation. Herein, in two model systems, the effects of diffusion-driven longitudinal relaxation are explored experimentally and analyzed quantitatively. In the first case, longitudinal relaxation in a single slice of a water phantom is monitored spectroscopically as a function of slice thickness. In the second case, mimicking vascular flow/diffusion effects, longitudinal relaxation is monitored in a two-compartment, semi-permeable fiber phantom. In both cases, apparent longitudinal relaxation, though clearly multi-exponential, is well-modeled as bi-exponential.
AB - Diffusion of spins between physical or virtual, communicating compartments having different states of longitudinal magnetization leads to diffusion-driven longitudinal relaxation. Herein, in two model systems, the effects of diffusion-driven longitudinal relaxation are explored experimentally and analyzed quantitatively. In the first case, longitudinal relaxation in a single slice of a water phantom is monitored spectroscopically as a function of slice thickness. In the second case, mimicking vascular flow/diffusion effects, longitudinal relaxation is monitored in a two-compartment, semi-permeable fiber phantom. In both cases, apparent longitudinal relaxation, though clearly multi-exponential, is well-modeled as bi-exponential.
KW - Flow
KW - MRI
KW - NMR
KW - Semi-permeable fiber
KW - Thin slice
UR - http://www.scopus.com/inward/record.url?scp=79958774919&partnerID=8YFLogxK
U2 - 10.1016/j.jmr.2011.03.018
DO - 10.1016/j.jmr.2011.03.018
M3 - Article
C2 - 21524595
AN - SCOPUS:79958774919
SN - 1090-7807
VL - 211
SP - 30
EP - 36
JO - Journal of Magnetic Resonance
JF - Journal of Magnetic Resonance
IS - 1
ER -