Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injury

Chao Zhou, Stephanie A. Eucker, Turgut Durduran, Guoqiang Yu, Jill Ralston, Stuart H. Friess, Rebecca N. Ichord, Susan S. Margulies, Arjun G. Yodh

Research output: Contribution to journalArticle

125 Scopus citations

Abstract

We used a nonimpact inertial rotational model of a closed head injury in neonatal piglets to simulate the conditions following traumatic brain injury in infants. Diffuse optical techniques, including diffuse reflectance spectroscopy and diffuse correlation spectroscopy (DCS), were used to measure cerebral blood oxygenation and blood flow continuously and noninvasively before injury and up to 6h after the injury. The DCS measurements of relative cerebral blood flow were validated against the fluorescent microsphere method. A strong linear correlation was observed between the two techniques (R=0.89, p<0.00001). Injury-induced cerebral hemodynamic changes were quantified, and significant changes were found in oxy- and deoxy-hemoglobin concentrations, total hemoglobin concentration, blood oxygen saturation, and cerebral blood flow after the injury. The diffuse optical measurements were robust and also correlated well with recordings of vital physiological parameters over the 6-h monitoring period, such as mean arterial blood pressure, arterial oxygen saturation, and heart rate. Finally, the diffuse optical techniques demonstrated sensitivity to dynamic physiological events, such as apnea, cardiac arrest, and hypertonic saline infusion. In total, the investigation corraborates potential of the optical methods for bedside monitoring of pediatric and adult human patients in the neurointensive care unit.

Original languageEnglish
Article number034015
JournalJournal of biomedical optics
Volume14
Issue number3
DOIs
StatePublished - Dec 1 2009
Externally publishedYes

Keywords

  • cerebral blood flow
  • cerebral hemodynamics
  • diffuse correlation spectroscopy (DCS)
  • diffuse reflectance spectroscopy (DRS)
  • near - infrared spectroscopy (NIRS)
  • traumatic brain injury

Fingerprint Dive into the research topics of 'Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injury'. Together they form a unique fingerprint.

  • Cite this

    Zhou, C., Eucker, S. A., Durduran, T., Yu, G., Ralston, J., Friess, S. H., Ichord, R. N., Margulies, S. S., & Yodh, A. G. (2009). Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injury. Journal of biomedical optics, 14(3), [034015]. https://doi.org/10.1117/1.3146814