Diffuse optical correlation tomography of cerebral blood flow during cortical spreading depression in rat brain

Chao Zhou, Guoqiang Yu, Daisuke Furuya, Joel H. Greenberg, Arjun G. Yodh, Turgut Durduran

Research output: Contribution to journalArticlepeer-review

197 Scopus citations

Abstract

Diffuse optical correlation methods were adapted for three-dimensional (3D) tomography of cerebral blood flow (CBF) in small animal models. The image reconstruction was optimized using a noise model for diffuse correlation tomography which enabled better data selection and regularization. The tomographic approach was demonstrated with simulated data and during in-vivo cortical spreading depression (CSD) in rat brain. Three-dimensional images of CBF were obtained through intact skull in tissues deep (∼ 4 mm) below the skull surface.

Original languageEnglish
Pages (from-to)1125-1144
Number of pages20
JournalOptics Express
Volume14
Issue number3
DOIs
StatePublished - Feb 2006

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