Abstract
Diffuse optical correlation methods were adapted for three-dimensional (3D) tomography of cerebral blood flow (CBF) in small animal models. The image reconstruction was optimized using a noise model for diffuse correlation tomography which enabled better data selection and regularization. The tomographic approach was demonstrated with simulated data and during in-vivo cortical spreading depression (CSD) in rat brain. Three-dimensional images of CBF were obtained through intact skull in tissues deep (∼ 4 mm) below the skull surface.
Original language | English |
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Pages (from-to) | 1125-1144 |
Number of pages | 20 |
Journal | Optics Express |
Volume | 14 |
Issue number | 3 |
DOIs | |
State | Published - Feb 2006 |