Diffuse idiopathic skeletal hyperostosis: A review

Fábio A. Nascimento, Luana Antunes Maranha Gatto, Roberto Oliver Lages, Heraldo Mello Neto, Zeferino Demartini Demartini, Gelson Luis Koppe

Research output: Contribution to journalArticlepeer-review

54 Scopus citations


Background: Diffuse idiopathic skeletal hyperostosis (DISH) is a systemic noninflammatory disease characterized by ossification of the entheses. Methods: This paper reviews the etiopathogenesis, epidemiology, clinical features, differential diagnosis, and treatment of DISH, based on current available literature. Results: Exact prevalence and incidence of DISH remains undetermined. Many external and genetic factors have been reported as being contributors to the pathogenesis of DISH. Current theories focus on the pathologic calcification of the anterior longitudinal ligament of the spine as the main physiopathological mechanism of disease. Clinical features are variable from monoarticular sinovitis to airway obstruction, and can be associated to systemic conditions. Comorbidities include obesity, hypertension, diabetes mellitus, hyperinsulinemia, dyslipidemia, and hyperuricemia according to a number of reports. Conclusions: DISH is a disease which involves the calcification of the anterior longitudinal ligament of the spine and can be associated with numerous clinical presentations and comorbidities. Copyright:

Original languageEnglish
Pages (from-to)S122-S125
JournalSurgical Neurology International
Issue numberSUPPL. 3
StatePublished - 2014


  • Anterior Longitudinal Ligament
  • Forestier's disease
  • diffuse idiopathic skeletal hyperostosis


Dive into the research topics of 'Diffuse idiopathic skeletal hyperostosis: A review'. Together they form a unique fingerprint.

Cite this