Differentiation of [3H]phencyclidine and ( + )-[3H]SKF-10,047 binding sites in rat cerebral cortex

Mark E. Goldman, Arthur E. Jacobson, Kenner C. Rice, Steven M. Paul

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


The potency of a series of opioid and non-opioid psychotomimetic drugs to inhibit the specific binding of [3H]PCP and ( + )-[3H]SKF-10,047 to rat cerebral cortical membranes was examined. ( + )-PCMP, the 3-methylpiperidino analog of PCP, was a potent inhibitor of the specific binding of both ligands. All of the other 12 compounds examined, however, displayed a 3-277-fold selectivity for either [3H]PCP or (+)-[3H]SKF-10,047 binding. These results suggest that although these opioid and non-opioid psychotomimetics bind to both sites, most have significantly different affinities. The binding sites for [3H]PCP appear to be distinct from the 'sigma' binding sites labeled with (+)-[3H]SKF-10,047. SKF-10,047 Sigma receptor Phencyclidine Phencyclidine receptor Psychotomimetic activity.

Original languageEnglish
Pages (from-to)333-336
Number of pages4
JournalFEBS Letters
Issue number2
StatePublished - Oct 14 1985


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