Differentiation of monocytes into dendritic cells in a model of transendothelial trafficking

Gwendalyn J. Randolph, Sylvie Beaulieu, Serge Lebecque, Ralph M. Steinman, William A. Muller

Research output: Contribution to journalReview articlepeer-review

682 Scopus citations

Abstract

Essential to the dendritic cell system of antigen-presenting cells are the veiled dendritic cells that traverse afferent lymph to enter lymph nodes, where they initiate immune responses. The origin of veiled cells, which were discovered 20 years ago, is unclear. Monocytes cultured with endothelium differentiated into dendritic cells within 2 days, particularly after phagocytosing particles in subendothelial collagen. These nascent dendritic cells migrated across the endothelium in the ablumenal-to-lumenal direction, as would occur during entry into lymphatics. Monocytes that remained in the subendothelial matrix became macrophages. Therefore, monocytes have two potential fates associated with distinct patterns of migration.

Original languageEnglish
Pages (from-to)480-483
Number of pages4
JournalScience
Volume282
Issue number5388
DOIs
StatePublished - Oct 16 1998

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