Differentiation of dystrophic and normal skeletal muscle tissues with energy and entropy images acquired In Vivo from the biceps of Mdx and wild-type mice

Kirk D. Wallace, Jon N. Marsh, Steven L. Baldwin, Anne M. Connolly, Richard Keeling, Gregory M. Lanza, Samuel A. Wickline, Michael S. Hughes

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Duchenne muscular dystrophy is a severe wasting disease, involving replacement of necrotic muscle tissue by fibrous material and fatty infiltrates. One primary animal model is the X chromosome-linked mdx strain of mice, which exhibit a clinical phenotype comparable to a mild expression of Duchenne muscular dystrophy in humans. The goals of the present work were to validate and quantify the capability of both energy and entropy metrics of radio-frequency ultrasonic backscatter to differentiate among normal, dystrophic, and steroid treated skeletal muscle in the mdx model.

Original languageEnglish
Title of host publication2006 IEEE International Ultrasonics Symposium, IUS
Pages1091-1094
Number of pages4
DOIs
StatePublished - Dec 1 2006

Publication series

NameProceedings - IEEE Ultrasonics Symposium
Volume1
ISSN (Print)1051-0117

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