TY - JOUR
T1 - Differentiation and self-renewal in the mouse gastrointestinal epithelium
AU - Gordon, Jeffrey I.
AU - Hermiston, Michelle L.
PY - 1994/12
Y1 - 1994/12
N2 - The mouse gut epithelium represents a dynamic, geographically well organized, developmental system for examining self-renewal and differentiation. Reagents are now available for identifying the molecular mechanisms that regulate cell fate in the gut, the migration-associated differentiation programs of its component cell lineages, and its axial patterning. Considerable attention needs to be paid to two variables when studying gastrointestinal epithelial cell biology: space and time. This has necessitated the use of normal, chimeric, and transgenic animals as experimental models.
AB - The mouse gut epithelium represents a dynamic, geographically well organized, developmental system for examining self-renewal and differentiation. Reagents are now available for identifying the molecular mechanisms that regulate cell fate in the gut, the migration-associated differentiation programs of its component cell lineages, and its axial patterning. Considerable attention needs to be paid to two variables when studying gastrointestinal epithelial cell biology: space and time. This has necessitated the use of normal, chimeric, and transgenic animals as experimental models.
UR - http://www.scopus.com/inward/record.url?scp=0028006911&partnerID=8YFLogxK
U2 - 10.1016/0955-0674(94)90047-7
DO - 10.1016/0955-0674(94)90047-7
M3 - Article
C2 - 7880525
AN - SCOPUS:0028006911
SN - 0955-0674
VL - 6
SP - 795
EP - 803
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
IS - 6
ER -