Differentiating tumor specimens by polarimetric speckle pattern analysis

Vahid Abbasian, Vahideh Farzam Rad, Parisa Shamshiripour, Davoud Ahmadvand, Arash Darafsheh

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


Definite diagnosis of brain neoplasms has been a challenge of neurosurgery practice especially when open surgery is not feasible to obtain adequate tissue samples for pathological investigation (e.g., for deep-seated tumors or tumors of eloquent areas undergoing biopsies or recurrent cases in patients that are candidates for palliative care). This complexity is exacerbated due to tumor heterogeneity, particularly when relying on limited samples obtained through stereotactic biopsies, which increases the risk of misdiagnosis. Addressing this critical issue, we propose a novel, label-free diagnostic approach by combining the strengths of polarimetry and speckle pattern analysis. This research introduces an innovative method that integrates Mueller matrix polarimetry with dynamic laser speckle analysis, offering a promising avenue for precise differentiation of biomedical samples and tissues. We validate the effectiveness of our technique by calculating the Mueller matrix images of the two various subtypes of brain neoplasms, followed by speckle pattern analysis through both numerical and graphical statistical post-processing. The results indicate considerable discrimination between the tissues, highlighting the potential of this methodology as an easily implementable non-invasive quantitative tool for analyzing extensive cancerous specimens.

Original languageEnglish
Title of host publicationOptical Interactions with Tissue and Cells XXXV
EditorsNorbert Linz, Joel N. Bixler, Alex J. Walsh
ISBN (Electronic)9781510669390
StatePublished - 2024
EventOptical Interactions with Tissue and Cells XXXV 2024 - San Francisco, United States
Duration: Jan 27 2024Jan 28 2024

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceOptical Interactions with Tissue and Cells XXXV 2024
Country/TerritoryUnited States
CitySan Francisco


  • brain neoplasms discrimination
  • Muller matrix
  • polarimetry.
  • speckle pattern


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