Differentiating among stages of cognitive impairment in aging: Version 3 of the Uniform Data Set (UDS) neuropsychological test battery and MoCA index scores

Hiroko H. Dodge; Felicia C. Goldstein; Nicole I. Wakim; Tamar Gefen; Merilee Teylan; Kwun C.G. Chan; Walter A. Kukull; Lisa L. Barnes; Bruno Giordani; Timothy M. Hughes; Joel H. Kramer; David A. Loewenstein; Daniel C. Marson; Dan M. Mungas; Nora Mattek; Bonnie C. Sachs; David P. Salmon; Monica Willis-Parker; Kathleen A. Welsh-Bohmer; Katherine V. Wild; John C. Morris; Sandra Weintraub

doi:10.1002/trc2.12103

Differentiating among stages of cognitive impairment in aging: Version 3 of the Uniform Data Set (UDS) neuropsychological test battery and MoCA index scores

Hiroko H. Dodge, Felicia C. Goldstein, Nicole I. Wakim, Tamar Gefen, Merilee Teylan, Kwun C.G. Chan, Walter A. Kukull, Lisa L. Barnes, Bruno Giordani, Timothy M. Hughes, Joel H. Kramer, David A. Loewenstein, Daniel C. Marson, Dan M. Mungas, Nora Mattek, Bonnie C. Sachs, David P. Salmon, Monica Willis-Parker, Kathleen A. Welsh-Bohmer, Katherine V. WildJohn C. Morris, Sandra Weintraub

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Introduction: Federally funded Alzheimer’s Disease Centers in the United States have been using a standardized neuropsychological test battery as part of the National Alzheimer’s Coordinating Center Uniform Data Set (UDS) since 2005. Version 3 (V3) of the UDS replaced the previous version (V2) in 2015.We compared V2 and V3 neuropsychological tests with respect to their ability to distinguish among the Clinical Dementia Rating (CDR) global scores of 0, 0.5, and 1. Methods: First, we matched participants receiving V2 tests (V2 cohort) and V3 tests (V3 cohort) in their cognitive functions using tests common to both versions. Then, we compared receiver-operating characteristic (ROC) area under the curve in differentiating CDRs for the remaining tests. Results: Some V3 tests performed better thanV2 tests in differentiating betweenCDR 0.5 and 0, but the improvement was limited to Caucasian participants. Discussion: Further efforts to improve the ability for early identification of cognitive decline among diverse racial groups are required.

Original language	English
Article number	e12103
Journal	Alzheimer's and Dementia: Translational Research and Clinical Interventions
Volume	6
Issue number	1
DOIs	https://doi.org/10.1002/trc2.12103
State	Published - 2020

Keywords

National Alzheimer’s Coordinating Center Uniform Data Set (NACC UDS)
differentiating CDR
optimal cut-point
racial differences
receiver-operating characteristic area under the curve (ROC-AUC)
validity

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10.1002/trc2.12103

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Dodge, H. H., Goldstein, F. C., Wakim, N. I., Gefen, T., Teylan, M., Chan, K. C. G., Kukull, W. A., Barnes, L. L., Giordani, B., Hughes, T. M., Kramer, J. H., Loewenstein, D. A., Marson, D. C., Mungas, D. M., Mattek, N., Sachs, B. C., Salmon, D. P., Willis-Parker, M., Welsh-Bohmer, K. A., ... Weintraub, S. (2020). Differentiating among stages of cognitive impairment in aging: Version 3 of the Uniform Data Set (UDS) neuropsychological test battery and MoCA index scores. Alzheimer's and Dementia: Translational Research and Clinical Interventions, 6(1), Article e12103. https://doi.org/10.1002/trc2.12103

@article{3aea7faefff84ae8837642063c0f4645,

title = "Differentiating among stages of cognitive impairment in aging: Version 3 of the Uniform Data Set (UDS) neuropsychological test battery and MoCA index scores",

abstract = "Introduction: Federally funded Alzheimer{\textquoteright}s Disease Centers in the United States have been using a standardized neuropsychological test battery as part of the National Alzheimer{\textquoteright}s Coordinating Center Uniform Data Set (UDS) since 2005. Version 3 (V3) of the UDS replaced the previous version (V2) in 2015.We compared V2 and V3 neuropsychological tests with respect to their ability to distinguish among the Clinical Dementia Rating (CDR) global scores of 0, 0.5, and 1. Methods: First, we matched participants receiving V2 tests (V2 cohort) and V3 tests (V3 cohort) in their cognitive functions using tests common to both versions. Then, we compared receiver-operating characteristic (ROC) area under the curve in differentiating CDRs for the remaining tests. Results: Some V3 tests performed better thanV2 tests in differentiating betweenCDR 0.5 and 0, but the improvement was limited to Caucasian participants. Discussion: Further efforts to improve the ability for early identification of cognitive decline among diverse racial groups are required.",

keywords = "National Alzheimer{\textquoteright}s Coordinating Center Uniform Data Set (NACC UDS), differentiating CDR, optimal cut-point, racial differences, receiver-operating characteristic area under the curve (ROC-AUC), validity",

author = "Dodge, {Hiroko H.} and Goldstein, {Felicia C.} and Wakim, {Nicole I.} and Tamar Gefen and Merilee Teylan and Chan, {Kwun C.G.} and Kukull, {Walter A.} and Barnes, {Lisa L.} and Bruno Giordani and Hughes, {Timothy M.} and Kramer, {Joel H.} and Loewenstein, {David A.} and Marson, {Daniel C.} and Mungas, {Dan M.} and Nora Mattek and Sachs, {Bonnie C.} and Salmon, {David P.} and Monica Willis-Parker and Welsh-Bohmer, {Kathleen A.} and Wild, {Katherine V.} and Morris, {John C.} and Sandra Weintraub",

note = "Publisher Copyright: {\textcopyright} 2020 The Authors.",

year = "2020",

doi = "10.1002/trc2.12103",

language = "English",

volume = "6",

journal = "Alzheimer's and Dementia: Translational Research and Clinical Interventions",

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Dodge, HH, Goldstein, FC, Wakim, NI, Gefen, T, Teylan, M, Chan, KCG, Kukull, WA, Barnes, LL, Giordani, B, Hughes, TM, Kramer, JH, Loewenstein, DA, Marson, DC, Mungas, DM, Mattek, N, Sachs, BC, Salmon, DP, Willis-Parker, M, Welsh-Bohmer, KA, Wild, KV, Morris, JC & Weintraub, S 2020, 'Differentiating among stages of cognitive impairment in aging: Version 3 of the Uniform Data Set (UDS) neuropsychological test battery and MoCA index scores', Alzheimer's and Dementia: Translational Research and Clinical Interventions, vol. 6, no. 1, e12103. https://doi.org/10.1002/trc2.12103

Differentiating among stages of cognitive impairment in aging: Version 3 of the Uniform Data Set (UDS) neuropsychological test battery and MoCA index scores. / Dodge, Hiroko H.; Goldstein, Felicia C.; Wakim, Nicole I. et al.
In: Alzheimer's and Dementia: Translational Research and Clinical Interventions, Vol. 6, No. 1, e12103, 2020.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Differentiating among stages of cognitive impairment in aging

T2 - Version 3 of the Uniform Data Set (UDS) neuropsychological test battery and MoCA index scores

AU - Dodge, Hiroko H.

AU - Goldstein, Felicia C.

AU - Wakim, Nicole I.

AU - Gefen, Tamar

AU - Teylan, Merilee

AU - Chan, Kwun C.G.

AU - Kukull, Walter A.

AU - Barnes, Lisa L.

AU - Giordani, Bruno

AU - Hughes, Timothy M.

AU - Kramer, Joel H.

AU - Loewenstein, David A.

AU - Marson, Daniel C.

AU - Mungas, Dan M.

AU - Mattek, Nora

AU - Sachs, Bonnie C.

AU - Salmon, David P.

AU - Willis-Parker, Monica

AU - Welsh-Bohmer, Kathleen A.

AU - Wild, Katherine V.

AU - Morris, John C.

AU - Weintraub, Sandra

PY - 2020

Y1 - 2020

N2 - Introduction: Federally funded Alzheimer’s Disease Centers in the United States have been using a standardized neuropsychological test battery as part of the National Alzheimer’s Coordinating Center Uniform Data Set (UDS) since 2005. Version 3 (V3) of the UDS replaced the previous version (V2) in 2015.We compared V2 and V3 neuropsychological tests with respect to their ability to distinguish among the Clinical Dementia Rating (CDR) global scores of 0, 0.5, and 1. Methods: First, we matched participants receiving V2 tests (V2 cohort) and V3 tests (V3 cohort) in their cognitive functions using tests common to both versions. Then, we compared receiver-operating characteristic (ROC) area under the curve in differentiating CDRs for the remaining tests. Results: Some V3 tests performed better thanV2 tests in differentiating betweenCDR 0.5 and 0, but the improvement was limited to Caucasian participants. Discussion: Further efforts to improve the ability for early identification of cognitive decline among diverse racial groups are required.

AB - Introduction: Federally funded Alzheimer’s Disease Centers in the United States have been using a standardized neuropsychological test battery as part of the National Alzheimer’s Coordinating Center Uniform Data Set (UDS) since 2005. Version 3 (V3) of the UDS replaced the previous version (V2) in 2015.We compared V2 and V3 neuropsychological tests with respect to their ability to distinguish among the Clinical Dementia Rating (CDR) global scores of 0, 0.5, and 1. Methods: First, we matched participants receiving V2 tests (V2 cohort) and V3 tests (V3 cohort) in their cognitive functions using tests common to both versions. Then, we compared receiver-operating characteristic (ROC) area under the curve in differentiating CDRs for the remaining tests. Results: Some V3 tests performed better thanV2 tests in differentiating betweenCDR 0.5 and 0, but the improvement was limited to Caucasian participants. Discussion: Further efforts to improve the ability for early identification of cognitive decline among diverse racial groups are required.

KW - National Alzheimer’s Coordinating Center Uniform Data Set (NACC UDS)

KW - differentiating CDR

KW - optimal cut-point

KW - racial differences

KW - receiver-operating characteristic area under the curve (ROC-AUC)

KW - validity

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U2 - 10.1002/trc2.12103

DO - 10.1002/trc2.12103

M3 - Article

AN - SCOPUS:85103963464

SN - 2352-8737

VL - 6

JO - Alzheimer's and Dementia: Translational Research and Clinical Interventions

JF - Alzheimer's and Dementia: Translational Research and Clinical Interventions

IS - 1

M1 - e12103

ER -

Differentiating among stages of cognitive impairment in aging: Version 3 of the Uniform Data Set (UDS) neuropsychological test battery and MoCA index scores

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Keywords

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