Differential vulnerability of white matter structures to experimental infantile hydrocephalus detected by diffusion tensor imaging

Ramin Eskandari, Osama Abdullah, Cameron Mason, Kelley E. Lloyd, Amanda N. Oeschle, James P. McAllister

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Results: In the corpus callosum during acute stages, fractional anisotropy (FA) decreased significantly with early and late reservoir placement (p = 0.0008 and 0.0008, respectively), and diffusivity increased significantly in early (axial, radial, and mean diffusivity, p = 0.0026, 0.0012, and 0.0002, respectively) and late (radial and mean diffusivity, p = 0.01 and 0.0038, respectively) groups. Chronically, the corpus callosum was thinned and not detectable by DTI. FA was significantly lower in the optic chiasm and tracts (p = 0.0496 and 0.0052, respectively) with late but not early reservoir placement. In the internal capsule, FA in both reservoir groups increased significantly with age (p < 0.05) but diffusivity remained unchanged.

Conclusions: All hydrocephalic animals treated with intermittent ventricular reservoir tapping demonstrated progressive ventriculomegaly. Both reservoir groups demonstrated WM integrity loss, with the CC the most vulnerable and the optic system the most resilient.

Purpose: The differential vulnerability of white matter (WM) to acute and chronic infantile hydrocephalus and the related effects of early and late reservoir treatment are unknown, but diffusion tensor imaging (DTI) could provide this information. Thus, we characterized WM integrity using DTI in a clinically relevant model.

Methods: Obstructive hydrocephalus was induced in 2-week-old felines by intracisternal kaolin injection. Ventricular reservoirs were placed 1 (early) or 2 (late) weeks post-kaolin and tapped frequently based solely on neurological deficit. Hydrocephalic and age-matched control animals were sacrificed 12 weeks postreservoir. WM integrity was evaluated in the optic system, corpus callosum, and internal capsule prereservoir and every 3 weeks using DTI. Analyses were grouped as acute (<6 weeks) or chronic (≥6 weeks).

Original languageEnglish
Pages (from-to)1651-1661
Number of pages11
JournalChild's Nervous System
Volume30
Issue number10
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Keywords

  • Diffusion tensor imaging
  • Infantile hydrocephalus
  • White matter

Fingerprint Dive into the research topics of 'Differential vulnerability of white matter structures to experimental infantile hydrocephalus detected by diffusion tensor imaging'. Together they form a unique fingerprint.

  • Cite this