TY - JOUR
T1 - Differential role of tumor necrosis factor receptors in TNBS colitis
AU - Ebach, Dawn R.
AU - Newberry, Rodney
AU - Stenson, William F.
PY - 2005/6
Y1 - 2005/6
N2 - Background: Tumor necrosis factor α (TNFα) plays a central role in the pathology of T helper 1-mediated colitis such as Crohn's disease; however, the role of its 2 receptors in mediating pathology has not been fully explored. Methods: Trinitrobenzene sulfonic acid colitis was used to induce colitis in mice lacking each of the TNF receptors (TNFRs) and in wild-type mice. TNFR1-/- mice lost more weight, became hypothermic, and had increased mortality compared with wild-type C57B1/6 mice. TNFR2-/- mice, however, lost less weight, had normal temperatures, and had improved survival. Results: Despite the improved clinical outcomes in TNFR2-/- mice, TNFα levels were increased in these mice. Conclusions: TNFα signaling through TNFR1 is protective in the trinitrobenzene sulfonic acid mouse model of inflammatory bowel disease.
AB - Background: Tumor necrosis factor α (TNFα) plays a central role in the pathology of T helper 1-mediated colitis such as Crohn's disease; however, the role of its 2 receptors in mediating pathology has not been fully explored. Methods: Trinitrobenzene sulfonic acid colitis was used to induce colitis in mice lacking each of the TNF receptors (TNFRs) and in wild-type mice. TNFR1-/- mice lost more weight, became hypothermic, and had increased mortality compared with wild-type C57B1/6 mice. TNFR2-/- mice, however, lost less weight, had normal temperatures, and had improved survival. Results: Despite the improved clinical outcomes in TNFR2-/- mice, TNFα levels were increased in these mice. Conclusions: TNFα signaling through TNFR1 is protective in the trinitrobenzene sulfonic acid mouse model of inflammatory bowel disease.
KW - Inflammatory bowel disease
KW - Trinitrobenzene sulfonic acid
KW - Tumor necrosis factor receptors
KW - Tumor necrosis factor α
UR - http://www.scopus.com/inward/record.url?scp=20444455344&partnerID=8YFLogxK
U2 - 10.1097/01.MIB.0000163698.34592.30
DO - 10.1097/01.MIB.0000163698.34592.30
M3 - Article
C2 - 15905700
AN - SCOPUS:20444455344
VL - 11
SP - 533
EP - 540
JO - Inflammatory Bowel Diseases
JF - Inflammatory Bowel Diseases
SN - 1078-0998
IS - 6
ER -