Differential regulation of 'central' and 'peripheral' benzodiazepine binding sites in the rat olfactory bulb

Gordon T. Bolger, Eva Mezey, Jerry Cott, Ben Avi Weissman, Steven M. Paul, Phil Skolnick

Research output: Contribution to journalArticle

45 Scopus citations

Abstract

The density of [3H]flunitrazepam and [3H]Ro 5-4864 binding sites was examined 19-21 and 27-31 days after surgical isolation of the olfactory bulbs. While statistically significant reductions in [3H]flunitrazepam binding were observed in the olfactory bulbs at both intervals, a significant reduction in [3H]Ro 5-4864 binding was observed only at 27-31 days after surgery. No consistent changes in the binding of either radioligand were observed in cerebella. Extirpation of the olfactory bulbs resulted in a significant reduction in the convulsant potency (but not efficacy) of Ro 5-4864, while neither the potency nor efficacy of pentylenetetrazole was affected by this procedure. These results suggest that benzodiazepine receptors and 'peripheral-type' binding sites for benzodiazepines are regulated independently, and that at least a subpopulation of peripheral-type binding sites are associated with neuronal elements in the olfactory bulb. These data also suggest that peripheral-type binding sites for benzodiazepines in the olfactory bulbs may influence the convulsant actions of Ro 5-4864.

Original languageEnglish
Pages (from-to)143-148
Number of pages6
JournalEuropean Journal of Pharmacology
Volume105
Issue number1-2
DOIs
StatePublished - Oct 1 1984
Externally publishedYes

Keywords

  • Benzodiazepine receptors
  • Convulsions
  • Lesions
  • Olfactory bulbs
  • Ro 5-4864

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