TY - JOUR
T1 - Differential phenotypic and functional properties of liver-resident NK cells and mucosal ILC1s
AU - Tang, Ling
AU - Peng, Hui
AU - Zhou, Jing
AU - Chen, Yongyan
AU - Wei, Haiming
AU - Sun, Rui
AU - Yokoyama, Wayne M.
AU - Tian, Zhigang
N1 - Funding Information:
We thank Dr. Tak W. Mak for providing Nfil3 +/− mice. This work was supported by the Ministry of Science & Technology of China (973 Basic Science Project) 2013CB944902 (Z.T.), Natural Science Foundation of China 81361120388 (Z.T.), 31300727 (H P.), 81571522 (H P.) and Key Program of the Chinese Academy of Sciences ( KJZD-EW-L10 -003 ) (R.S., Z.T.).
Publisher Copyright:
© 2015 Elsevier Ltd.
PY - 2016/2/1
Y1 - 2016/2/1
N2 - Group 1 innate lymphoid cells (ILCs) consist of conventional natural killer (cNK) cells, tissue-resident NK cells and mucosal ILC1s. Recently identified liver-resident NK cells, which can mount contact hypersensitivity responses, and mucosal ILC1s that are involved in pathogenesis of colitis are distinct from cNK cells in several aspects, but the issue of how they are related to each other has not been clearly clarified. Here, we show that liver-resident NK cells and mucosal ILC1s have different phenotypes, as evidenced by distinct expression patterns of homing-associated molecules. Moreover, mucosal ILC1s exhibit tissue residency akin to liver-resident NK cells. Importantly, liver-resident NK cells express relative high levels of cytotoxic effector molecules, which are poorly expressed by mucosal ILC1s, and exhibit stronger cytotoxic activity compared with mucosal ILC1s. These results demonstrate differential phenotypic and functional characteristics of liver-resident NK cells and mucosal ILC1s, shedding new light on the diversity of ILC family.
AB - Group 1 innate lymphoid cells (ILCs) consist of conventional natural killer (cNK) cells, tissue-resident NK cells and mucosal ILC1s. Recently identified liver-resident NK cells, which can mount contact hypersensitivity responses, and mucosal ILC1s that are involved in pathogenesis of colitis are distinct from cNK cells in several aspects, but the issue of how they are related to each other has not been clearly clarified. Here, we show that liver-resident NK cells and mucosal ILC1s have different phenotypes, as evidenced by distinct expression patterns of homing-associated molecules. Moreover, mucosal ILC1s exhibit tissue residency akin to liver-resident NK cells. Importantly, liver-resident NK cells express relative high levels of cytotoxic effector molecules, which are poorly expressed by mucosal ILC1s, and exhibit stronger cytotoxic activity compared with mucosal ILC1s. These results demonstrate differential phenotypic and functional characteristics of liver-resident NK cells and mucosal ILC1s, shedding new light on the diversity of ILC family.
KW - Conventional NK cell
KW - Cytotoxicity
KW - ILC1
KW - Liver-resident NK cell
KW - Phenotype
UR - http://www.scopus.com/inward/record.url?scp=84957434981&partnerID=8YFLogxK
U2 - 10.1016/j.jaut.2015.09.004
DO - 10.1016/j.jaut.2015.09.004
M3 - Article
C2 - 26422992
AN - SCOPUS:84957434981
SN - 0896-8411
VL - 67
SP - 29
EP - 35
JO - Journal of Autoimmunity
JF - Journal of Autoimmunity
ER -