Differential osteoclast activation in endochondral and intramembranous bone

Richard A. Chole

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Osteoclast activation within the temporal bone leads to hearing loss in a variety of pathologic conditions, including otosclerosis, osteogenesis imperfecta, Paget’s disease of bone, and chronic otitis media. Although endochondral (EC) bone is remodeled in these diseases, it is relatively more resistant to remodeling when compared to intramembranous (IM) bone. In this study, localized bone resorption and remodeling were induced on the inner surface of the middle ear by pressurization with air to 10 mm Hg above atmospheric. Osteoclast surface increased in IM bone, but not in EC bone. This study supports the concept that there may be fundamental differences between EC and IM bone and that EC is more resistant to pressure-induced localized resorption than IM bone.

Original languageEnglish
Pages (from-to)616-619
Number of pages4
JournalAnnals of Otology, Rhinology & Laryngology
Issue number8
StatePublished - Aug 1993


  • endochondral bone
  • intramembranous bone
  • osteoclast


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