Differential electrophysiological and behavioral responses to optically active derivatives of phencyclidine

Jwaharlal Marwaha, Michael Palmer, Barry Hoffer, Robert Freedman, Kenner C. Rice, Steven Paul, Phil Skolnick

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Dextro-and levorotatory isomers of 1-(1-phenylcyclohexyl)-3-methylpiperidine (PCMP) were synthesized. Both isomers inhibited spontaneous cerebellar Purkinje neuron firing when applied locally by pressure ejection. This effect was dose-dependent, with the (+)-isomer about 5-7 times more potent than the (-)-isomer. Both isomers also depressed rotarod performance in mice. Again, the (+)-isomer was about 5 times more potent than the (-)-isomer. Both rotarod performance and Purkinje cell discharge were depressed maximally 10-15 min after i.p. injection of drug. Our results suggest a correlation between behavioral performance and central neuron electrophysiological activity and suggest that the central actions of PCP or its derivatives are probably mediated at one locus, by a stereospecific mechanism.

Original languageEnglish
Pages (from-to)203-209
Number of pages7
JournalNaunyn-Schmiedeberg's Archives of Pharmacology
Volume315
Issue number3
DOIs
StatePublished - Jan 1981

Keywords

  • (+)-PCMP
  • (-)-PCMP
  • Pressure ejection Rotarod behavior
  • Purkinje neurons

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