TY - JOUR
T1 - Differential Diagnosis of Proliferative Breast Lesions
AU - Simpson, Jean F.
AU - Boulos, Fouad I.
PY - 2009/6
Y1 - 2009/6
N2 - The correct diagnosis of proliferations within the mammary terminal duct-lobular unit has paramount prognostic and therapeutic implications. Occasionally, the differential diagnosis of compact florid hyperplasia, atypical ductal hyperplasia, and low-grade ductal carcinoma in situ can be quite challenging, with seeming morphologic overlap. This article presents s conceptual and practical understanding of these processes and their impact on subsequent cancer risk, with the intention of assisting the practicing pathologist render accurate and clinically relevant diagnoses for this frequently encountered set of mammary epithelial lesions.
AB - The correct diagnosis of proliferations within the mammary terminal duct-lobular unit has paramount prognostic and therapeutic implications. Occasionally, the differential diagnosis of compact florid hyperplasia, atypical ductal hyperplasia, and low-grade ductal carcinoma in situ can be quite challenging, with seeming morphologic overlap. This article presents s conceptual and practical understanding of these processes and their impact on subsequent cancer risk, with the intention of assisting the practicing pathologist render accurate and clinically relevant diagnoses for this frequently encountered set of mammary epithelial lesions.
KW - Ductal carcinoma in situ
KW - Epithelial proliferative disease
UR - http://www.scopus.com/inward/record.url?scp=66049087528&partnerID=8YFLogxK
U2 - 10.1016/j.path.2009.02.002
DO - 10.1016/j.path.2009.02.002
M3 - Review article
AN - SCOPUS:66049087528
SN - 1875-9181
VL - 2
SP - 235
EP - 246
JO - Surgical Pathology Clinics
JF - Surgical Pathology Clinics
IS - 2
ER -