TY - JOUR
T1 - Differential components of bradykinesia in Parkinson's disease revealed by deep brain stimulation
AU - Mazzoni, Pietro
AU - Ushe, Mwiza
AU - Younce, John R.
AU - Norris, Scott A.
AU - Hershey, Tamara
AU - Karimi, Morvarid
AU - Tabbal, Samer D.
AU - Perlmutter, Joel S.
N1 - Publisher Copyright:
© 2024 the American Physiological Society.
PY - 2024/9
Y1 - 2024/9
N2 - Bradykinesia is a term describing several manifestations of movement disruption caused by Parkinson’s disease (PD), including movement slowing, amplitude reduction, and gradual decrease of speed and amplitude over multiple repetitions of the same movement. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) improves bradykinesia in patients with PD. We examined the effect of DBS on specific components of bradykinesia when applied at two locations within the STN, using signal processing techniques to identify the time course of amplitude and frequency of repeated hand pronation-supination movements performed by participants with and without PD. Stimulation at either location increased movement amplitude, increased frequency, and decreased variability, though not to the range observed in the control group. Amplitude and frequency showed decrement within trials, which was similar in PD and control groups and did not change with DBS. Decrement across trials, by contrast, differed between PD and control groups, and was reduced by stimulation. We conclude that DBS improves specific aspects of movement that are disrupted by PD, whereas it does not affect short-term decrement that could reflect muscular fatigue. NEW & NOTEWORTHY In this study, we examined different components of bradykinesia in patients with Parkinson’s disease (PD). We identified different components through signal processing techniques and their response to deep brain stimulation (DBS). We found that some components of bradykinesia respond to stimulation, whereas others do not. This knowledge advances our understanding of brain mechanisms that control movement speed and amplitude.
AB - Bradykinesia is a term describing several manifestations of movement disruption caused by Parkinson’s disease (PD), including movement slowing, amplitude reduction, and gradual decrease of speed and amplitude over multiple repetitions of the same movement. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) improves bradykinesia in patients with PD. We examined the effect of DBS on specific components of bradykinesia when applied at two locations within the STN, using signal processing techniques to identify the time course of amplitude and frequency of repeated hand pronation-supination movements performed by participants with and without PD. Stimulation at either location increased movement amplitude, increased frequency, and decreased variability, though not to the range observed in the control group. Amplitude and frequency showed decrement within trials, which was similar in PD and control groups and did not change with DBS. Decrement across trials, by contrast, differed between PD and control groups, and was reduced by stimulation. We conclude that DBS improves specific aspects of movement that are disrupted by PD, whereas it does not affect short-term decrement that could reflect muscular fatigue. NEW & NOTEWORTHY In this study, we examined different components of bradykinesia in patients with Parkinson’s disease (PD). We identified different components through signal processing techniques and their response to deep brain stimulation (DBS). We found that some components of bradykinesia respond to stimulation, whereas others do not. This knowledge advances our understanding of brain mechanisms that control movement speed and amplitude.
KW - DBS
KW - kinematics
KW - motor control
KW - movement
KW - wearable sensors
UR - http://www.scopus.com/inward/record.url?scp=85203302116&partnerID=8YFLogxK
U2 - 10.1152/jn.00320.2022
DO - 10.1152/jn.00320.2022
M3 - Article
C2 - 38985938
AN - SCOPUS:85203302116
SN - 0022-3077
VL - 132
SP - 870
EP - 878
JO - Journal of neurophysiology
JF - Journal of neurophysiology
IS - 3
ER -