Differential characterization of blood flow, velocity, and vascular resistance between proximal and distal normal epicardial human coronary arteries: Analysis by intracoronary Doppler spectral flow velocity

Elizabeth O. Ofili, Morton J. Kern, Jeanette A. St. Vrain, Thomas J. Donohue, Richard Bach, Bassam Al-Joundi, Frank V. Aguirre, Ramon Castello, Arthur J. Labovitz

Research output: Contribution to journalArticlepeer-review

69 Scopus citations

Abstract

To characterize coronary blood flow velocity parameters and to determine the relation among velocity, volumetric flow, and vascular resistance in awake human beings, we performed paired proximal and distal velocity measurements in 28 angiographically normal coronary arteries. Mean velocity, peak velocity, diastolic-to-systolic velocity ratio, and diameter and cross-sectional area of proximal and distal arteries were determined and coronary flow and vascular resistance computed. Mean velocity and coronary vasodilator reserve were similar for all three native arteries and were preserved from proximal to distal segments. Volumetric flow decreased from proximal to distal segments. The demonstrated inverse and curvilinear (polynomial) relation between volumetric flow and vascular resistance agrees with theoretical and animal models of coronary physiologic characteristics and suggests a nadir of coronary vascular resistance below which coronary flow no longer increases.

Original languageEnglish
Pages (from-to)37-46
Number of pages10
JournalAmerican heart journal
Volume130
Issue number1
DOIs
StatePublished - Jul 1995

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