TY - JOUR
T1 - Differential characterization of blood flow, velocity, and vascular resistance between proximal and distal normal epicardial human coronary arteries
T2 - Analysis by intracoronary Doppler spectral flow velocity
AU - Ofili, Elizabeth O.
AU - Kern, Morton J.
AU - St. Vrain, Jeanette A.
AU - Donohue, Thomas J.
AU - Bach, Richard
AU - Al-Joundi, Bassam
AU - Aguirre, Frank V.
AU - Castello, Ramon
AU - Labovitz, Arthur J.
PY - 1995/7
Y1 - 1995/7
N2 - To characterize coronary blood flow velocity parameters and to determine the relation among velocity, volumetric flow, and vascular resistance in awake human beings, we performed paired proximal and distal velocity measurements in 28 angiographically normal coronary arteries. Mean velocity, peak velocity, diastolic-to-systolic velocity ratio, and diameter and cross-sectional area of proximal and distal arteries were determined and coronary flow and vascular resistance computed. Mean velocity and coronary vasodilator reserve were similar for all three native arteries and were preserved from proximal to distal segments. Volumetric flow decreased from proximal to distal segments. The demonstrated inverse and curvilinear (polynomial) relation between volumetric flow and vascular resistance agrees with theoretical and animal models of coronary physiologic characteristics and suggests a nadir of coronary vascular resistance below which coronary flow no longer increases.
AB - To characterize coronary blood flow velocity parameters and to determine the relation among velocity, volumetric flow, and vascular resistance in awake human beings, we performed paired proximal and distal velocity measurements in 28 angiographically normal coronary arteries. Mean velocity, peak velocity, diastolic-to-systolic velocity ratio, and diameter and cross-sectional area of proximal and distal arteries were determined and coronary flow and vascular resistance computed. Mean velocity and coronary vasodilator reserve were similar for all three native arteries and were preserved from proximal to distal segments. Volumetric flow decreased from proximal to distal segments. The demonstrated inverse and curvilinear (polynomial) relation between volumetric flow and vascular resistance agrees with theoretical and animal models of coronary physiologic characteristics and suggests a nadir of coronary vascular resistance below which coronary flow no longer increases.
UR - http://www.scopus.com/inward/record.url?scp=0029016955&partnerID=8YFLogxK
U2 - 10.1016/0002-8703(95)90233-3
DO - 10.1016/0002-8703(95)90233-3
M3 - Article
C2 - 7611121
AN - SCOPUS:0029016955
VL - 130
SP - 37
EP - 46
JO - American Heart Journal
JF - American Heart Journal
SN - 0002-8703
IS - 1
ER -