Abstract
Herpes simplex virus 1 (HSV-1) and HSV-2 establish latency in different neuronal subtypes (A5+and KH10+) in murine trigeminal ganglia, results which correlate with restricted productive infection in these neurons in vitro. HSV-2 latency-associated transcript (LAT) contains a cis-acting regulatory element near the transcription start site that promotes productive infection in A5+ neurons and a second element in exon 1 that inhibits productive infection in KH10+ neurons. HSV-1 contains no such regulatory sequences, demonstrating different mechanisms for regulating productive HSV infection in neurons.
Original language | English |
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Pages (from-to) | 6512-6516 |
Number of pages | 5 |
Journal | Journal of virology |
Volume | 87 |
Issue number | 11 |
DOIs | |
State | Published - Jun 2013 |