Different epidermal growth factor (EGF) receptor ligands show distinct kinetics and biased or partial agonism for homodimer and heterodimer formation

Jennifer L. Macdonald-Obermann, Linda J. Pike

Research output: Contribution to journalArticlepeer-review

85 Scopus citations

Abstract

Background: The EGF receptor has multiple ligands that can induce different biological effects.

Results: EGF and TGFα, but not BTC or AREG, bias the EGF receptor toward heterodimer formation with ErbB2. AREG induces dimerization with different kinetics than the other ligands.

Conclusion: EGFR ligands differentially induce receptor dimerization.

Significance: This contributes to the biological differences elicited by different ligands.

Original languageEnglish
Pages (from-to)26178-26188
Number of pages11
JournalJournal of Biological Chemistry
Volume289
Issue number38
DOIs
StatePublished - Sep 19 2014

Fingerprint

Dive into the research topics of 'Different epidermal growth factor (EGF) receptor ligands show distinct kinetics and biased or partial agonism for homodimer and heterodimer formation'. Together they form a unique fingerprint.

Cite this