Background: The EGF receptor has multiple ligands that can induce different biological effects.
Results: EGF and TGFα, but not BTC or AREG, bias the EGF receptor toward heterodimer formation with ErbB2. AREG induces dimerization with different kinetics than the other ligands.
Conclusion: EGFR ligands differentially induce receptor dimerization.
Significance: This contributes to the biological differences elicited by different ligands.