Abstract
Background: The EGF receptor has multiple ligands that can induce different biological effects.
Results: EGF and TGFα, but not BTC or AREG, bias the EGF receptor toward heterodimer formation with ErbB2. AREG induces dimerization with different kinetics than the other ligands.
Conclusion: EGFR ligands differentially induce receptor dimerization.
Significance: This contributes to the biological differences elicited by different ligands.
Original language | English |
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Pages (from-to) | 26178-26188 |
Number of pages | 11 |
Journal | Journal of Biological Chemistry |
Volume | 289 |
Issue number | 38 |
DOIs | |
State | Published - Sep 19 2014 |