Different epidermal growth factor (EGF) receptor ligands show distinct kinetics and biased or partial agonism for homodimer and heterodimer formation

Jennifer L. Macdonald-Obermann, Linda J. Pike

Research output: Contribution to journalArticlepeer-review

66 Scopus citations

Abstract

Background: The EGF receptor has multiple ligands that can induce different biological effects.

Results: EGF and TGFα, but not BTC or AREG, bias the EGF receptor toward heterodimer formation with ErbB2. AREG induces dimerization with different kinetics than the other ligands.

Conclusion: EGFR ligands differentially induce receptor dimerization.

Significance: This contributes to the biological differences elicited by different ligands.

Original languageEnglish
Pages (from-to)26178-26188
Number of pages11
JournalJournal of Biological Chemistry
Volume289
Issue number38
DOIs
StatePublished - Sep 19 2014

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