TY - JOUR
T1 - Differences in histoplasmosis in patients with acquired immunodeficiency syndrome in the United States and Brazil
AU - Karimi, Kian
AU - Wheat, L. Joseph
AU - Connolly, Patricia
AU - Cloud, Gretchen
AU - Hajjeh, Rana
AU - Wheat, Emerson
AU - Alves, Katia
AU - Da Silva Lacaz, Carlos
AU - Keath, Elizabeth
N1 - Funding Information:
Financial support: Department of Veterans Affairs, National Institutes of Allergy and Infectious Diseases Mycoses Study Group (merit review grant NO1-RR0255A); AIDS Clinical Trials Group (AI25859 to L.J.W.); Coor-denacao de Aperfeicoamento de Pessoal de Nivel Superior and Fundacao de Amparo a Pesquisa do Estado de São Paulo (grant 94/4854-1). E.K. is a Burroughs Wellcome Scholar in Pathogenic Mycology, and K.A. is a Fogarty Fellow (D43-TW00003).
PY - 2002/12/1
Y1 - 2002/12/1
N2 - Demographic and clinical parameters among patients with acquired immunodeficiency syndrome and histoplasmosis in Brazil and United States were compared. The Brazilian isolates were typed by restriction-fragment length polymorphism analysis and were DNA fingerprinted by random amplification of polymorphic DNA (RAPD) - polymerase chain reaction (PCR). Skin lesions occurred in 66% of Brazilian case patients, compared with 1%-7% of US case patients. Of 21 treated case patients, 4 (19%) died, a rate similar to that of the US case patients (5%-13%). By nuclear gene typing, the Brazilian isolates were equally divided between South American classes 5 and 6, and RAPD-PCR showed 18 distinct genetic fingerprints in 20 isolates. Skin lesions are more common in infection with class 5 or 6 organisms than with class 2 Histoplasma capsulatum. The role of genetic differences in the organism as a cause for the clinical differences requires investigation.
AB - Demographic and clinical parameters among patients with acquired immunodeficiency syndrome and histoplasmosis in Brazil and United States were compared. The Brazilian isolates were typed by restriction-fragment length polymorphism analysis and were DNA fingerprinted by random amplification of polymorphic DNA (RAPD) - polymerase chain reaction (PCR). Skin lesions occurred in 66% of Brazilian case patients, compared with 1%-7% of US case patients. Of 21 treated case patients, 4 (19%) died, a rate similar to that of the US case patients (5%-13%). By nuclear gene typing, the Brazilian isolates were equally divided between South American classes 5 and 6, and RAPD-PCR showed 18 distinct genetic fingerprints in 20 isolates. Skin lesions are more common in infection with class 5 or 6 organisms than with class 2 Histoplasma capsulatum. The role of genetic differences in the organism as a cause for the clinical differences requires investigation.
UR - https://www.scopus.com/pages/publications/0036891038
U2 - 10.1086/345724
DO - 10.1086/345724
M3 - Article
C2 - 12447743
AN - SCOPUS:0036891038
SN - 0022-1899
VL - 186
SP - 1655
EP - 1660
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 11
ER -