Dietary nitrate's effects on exercise performance in heart failure with reduced ejection fraction (HFrEF)

Vinaya Mulkareddy, Susan B. Racette, Andrew R. Coggan, Linda R. Peterson

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Heart failure with reduced ejection fraction (HFrEF) is a deadly and disabling disease. A key derangement contributing to impaired exercise performance in HFrEF is decreased nitric oxide (NO) bioavailability. Scientists recently discovered the inorganic nitrate pathway for increasing NO. This has advantages over organic nitrates and NO synthase production of NO. Small studies using beetroot juice as a source of inorganic nitrate demonstrate its power to improve exercise performance in HFrEF. A larger-scale trial is now underway to determine if inorganic nitrate may be a new arrow for physicians' quiver of HFrEF treatments.

Original languageEnglish
Pages (from-to)735-740
Number of pages6
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
Volume1865
Issue number4
DOIs
StatePublished - Apr 1 2019

Keywords

  • Exercise performance
  • Heart failure
  • Inorganic nitrate
  • Muscle power
  • Nitric oxide
  • Peak oxygen consumption

Fingerprint

Dive into the research topics of 'Dietary nitrate's effects on exercise performance in heart failure with reduced ejection fraction (HFrEF)'. Together they form a unique fingerprint.

Cite this