Dietary nitrate's effects on exercise performance in heart failure with reduced ejection fraction (HFrEF)

Vinaya Mulkareddy; Susan B. Racette; Andrew R. Coggan; Linda R. Peterson

doi:10.1016/j.bbadis.2018.09.026

Dietary nitrate's effects on exercise performance in heart failure with reduced ejection fraction (HFrEF)

Vinaya Mulkareddy, Susan B. Racette, Andrew R. Coggan, Linda R. Peterson

Research output: Contribution to journal › Review article › peer-review

8 Scopus citations

Abstract

Heart failure with reduced ejection fraction (HFrEF) is a deadly and disabling disease. A key derangement contributing to impaired exercise performance in HFrEF is decreased nitric oxide (NO) bioavailability. Scientists recently discovered the inorganic nitrate pathway for increasing NO. This has advantages over organic nitrates and NO synthase production of NO. Small studies using beetroot juice as a source of inorganic nitrate demonstrate its power to improve exercise performance in HFrEF. A larger-scale trial is now underway to determine if inorganic nitrate may be a new arrow for physicians' quiver of HFrEF treatments.

Original language	English
Pages (from-to)	735-740
Number of pages	6
Journal	Biochimica et Biophysica Acta - Molecular Basis of Disease
Volume	1865
Issue number	4
DOIs	https://doi.org/10.1016/j.bbadis.2018.09.026
State	Published - Apr 1 2019

Keywords

Exercise performance
Heart failure
Inorganic nitrate
Muscle power
Nitric oxide
Peak oxygen consumption

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10.1016/j.bbadis.2018.09.026

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title = "Dietary nitrate's effects on exercise performance in heart failure with reduced ejection fraction (HFrEF)",

abstract = "Heart failure with reduced ejection fraction (HFrEF) is a deadly and disabling disease. A key derangement contributing to impaired exercise performance in HFrEF is decreased nitric oxide (NO) bioavailability. Scientists recently discovered the inorganic nitrate pathway for increasing NO. This has advantages over organic nitrates and NO synthase production of NO. Small studies using beetroot juice as a source of inorganic nitrate demonstrate its power to improve exercise performance in HFrEF. A larger-scale trial is now underway to determine if inorganic nitrate may be a new arrow for physicians' quiver of HFrEF treatments.",

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AU - Mulkareddy, Vinaya

AU - Racette, Susan B.

AU - Coggan, Andrew R.

AU - Peterson, Linda R.

PY - 2019/4/1

Y1 - 2019/4/1

N2 - Heart failure with reduced ejection fraction (HFrEF) is a deadly and disabling disease. A key derangement contributing to impaired exercise performance in HFrEF is decreased nitric oxide (NO) bioavailability. Scientists recently discovered the inorganic nitrate pathway for increasing NO. This has advantages over organic nitrates and NO synthase production of NO. Small studies using beetroot juice as a source of inorganic nitrate demonstrate its power to improve exercise performance in HFrEF. A larger-scale trial is now underway to determine if inorganic nitrate may be a new arrow for physicians' quiver of HFrEF treatments.

AB - Heart failure with reduced ejection fraction (HFrEF) is a deadly and disabling disease. A key derangement contributing to impaired exercise performance in HFrEF is decreased nitric oxide (NO) bioavailability. Scientists recently discovered the inorganic nitrate pathway for increasing NO. This has advantages over organic nitrates and NO synthase production of NO. Small studies using beetroot juice as a source of inorganic nitrate demonstrate its power to improve exercise performance in HFrEF. A larger-scale trial is now underway to determine if inorganic nitrate may be a new arrow for physicians' quiver of HFrEF treatments.

KW - Exercise performance

KW - Heart failure

KW - Inorganic nitrate

KW - Muscle power

KW - Nitric oxide

KW - Peak oxygen consumption

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SN - 0925-4439

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JO - Biochimica et Biophysica Acta - Molecular Basis of Disease

JF - Biochimica et Biophysica Acta - Molecular Basis of Disease

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ER -

Dietary nitrate's effects on exercise performance in heart failure with reduced ejection fraction (HFrEF)

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