TY - JOUR
T1 - Dietary Nitrate Increases VO2peak and Performance but Does Not Alter Ventilation or Efficiency in Patients With Heart Failure With Reduced Ejection Fraction
AU - Coggan, Andrew R.
AU - Broadstreet, Seth R.
AU - Mahmood, Kiran
AU - Mikhalkova, Deana
AU - Madigan, Michael
AU - Bole, Indra
AU - Park, Soo
AU - Leibowitz, Joshua L.
AU - Kadkhodayan, Ana
AU - Thomas, Deepak P.
AU - Thies, Dakkota
AU - Peterson, Linda R.
N1 - Publisher Copyright:
© 2017 Elsevier Inc.
PY - 2018/2
Y1 - 2018/2
N2 - Background: Patients with heart failure with reduced ejection fraction (HFrEF) exhibit lower efficiency, dyspnea, and diminished peak oxygen uptake (VO2peak) during exercise. Dietary nitrate (NO3 −), a source of nitric oxide (NO), has improved these measures in some studies of other populations. We determined the effects of acute NO3 − ingestion on exercise responses in 8 patients with HFrEF using a randomized, double-blind, placebo-controlled, crossover design. Methods and Results: Plasma NO3 −, nitrite (NO2 −), and breath NO were measured at multiple time points and respiratory gas exchange was determined during exercise after ingestion of beetroot juice containing or devoid of 11.2 mmol of NO3 −. NO3 − intake increased (P <.05–0.001) plasma NO3 − and NO2 − and breath NO by 1469 ± 245%, 105 ± 34%, and 60 ± 18%, respectively. Efficiency and ventilation during exercise were unchanged. However, NO3 − ingestion increased (P <.05) VO2peak by 8 ± 2% (ie, from 21.4 ± 2.1 to 23.0 ± 2.3 mL.min−1.kg−1). Time to fatigue improved (P <.05) by 7 ± 3 % (ie, from 582 ± 84 to 612 ± 81 seconds). Conclusions: Acute dietary NO3 − intake increases VO2peak and performance in patients with HFrEF. These data, in conjunction with our recent data demonstrating that dietary NO3 − also improves muscle contractile function, suggest that dietary NO3 − supplementation may be a valuable means of enhancing exercise capacity in this population.
AB - Background: Patients with heart failure with reduced ejection fraction (HFrEF) exhibit lower efficiency, dyspnea, and diminished peak oxygen uptake (VO2peak) during exercise. Dietary nitrate (NO3 −), a source of nitric oxide (NO), has improved these measures in some studies of other populations. We determined the effects of acute NO3 − ingestion on exercise responses in 8 patients with HFrEF using a randomized, double-blind, placebo-controlled, crossover design. Methods and Results: Plasma NO3 −, nitrite (NO2 −), and breath NO were measured at multiple time points and respiratory gas exchange was determined during exercise after ingestion of beetroot juice containing or devoid of 11.2 mmol of NO3 −. NO3 − intake increased (P <.05–0.001) plasma NO3 − and NO2 − and breath NO by 1469 ± 245%, 105 ± 34%, and 60 ± 18%, respectively. Efficiency and ventilation during exercise were unchanged. However, NO3 − ingestion increased (P <.05) VO2peak by 8 ± 2% (ie, from 21.4 ± 2.1 to 23.0 ± 2.3 mL.min−1.kg−1). Time to fatigue improved (P <.05) by 7 ± 3 % (ie, from 582 ± 84 to 612 ± 81 seconds). Conclusions: Acute dietary NO3 − intake increases VO2peak and performance in patients with HFrEF. These data, in conjunction with our recent data demonstrating that dietary NO3 − also improves muscle contractile function, suggest that dietary NO3 − supplementation may be a valuable means of enhancing exercise capacity in this population.
KW - Nitric oxide
KW - VOpeak
KW - exercise
KW - heart failure
UR - http://www.scopus.com/inward/record.url?scp=85030842296&partnerID=8YFLogxK
U2 - 10.1016/j.cardfail.2017.09.004
DO - 10.1016/j.cardfail.2017.09.004
M3 - Article
C2 - 28916479
AN - SCOPUS:85030842296
SN - 1071-9164
VL - 24
SP - 65
EP - 73
JO - Journal of cardiac failure
JF - Journal of cardiac failure
IS - 2
ER -