Dietary Nitrate Enhances the Contractile Properties of Human Skeletal Muscle

Andrew R. Coggan; Linda R. Peterson

doi:10.1249/JES.0000000000000167

Dietary Nitrate Enhances the Contractile Properties of Human Skeletal Muscle

Andrew R. Coggan, Linda R. Peterson

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

Abstract

Dietary nitrate, a source of nitric oxide (NO), improves the contractile properties of human muscle. We present the hypothesis that this is due to nitrosylation of the ryanodine receptor and increased NO signaling via the soluble guanyl cyclase-cyclic guanosine monophosphate-protein kinase G pathway, which together increase the free intracellular Ca²⁺ concentration along with the Ca²⁺ sensitivity of the myofilaments themselves.

Original language	English
Pages (from-to)	254-261
Number of pages	8
Journal	Exercise and Sport Sciences Reviews
Volume	46
Issue number	4
DOIs	https://doi.org/10.1249/JES.0000000000000167
State	Published - Oct 1 2018

Keywords

calcium sensitivity
cyclic guanosine monophosphate
dietary nitrate
free intracellular calcium
muscle contractile function
nitric oxide
ryanodine receptor

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10.1249/JES.0000000000000167

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abstract = "Dietary nitrate, a source of nitric oxide (NO), improves the contractile properties of human muscle. We present the hypothesis that this is due to nitrosylation of the ryanodine receptor and increased NO signaling via the soluble guanyl cyclase-cyclic guanosine monophosphate-protein kinase G pathway, which together increase the free intracellular Ca2+ concentration along with the Ca2+ sensitivity of the myofilaments themselves.",

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Dietary Nitrate Enhances the Contractile Properties of Human Skeletal Muscle

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Keywords

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