Dietary Nitrate Enhances the Contractile Properties of Human Skeletal Muscle

Andrew R. Coggan, Linda R. Peterson

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


Dietary nitrate, a source of nitric oxide (NO), improves the contractile properties of human muscle. We present the hypothesis that this is due to nitrosylation of the ryanodine receptor and increased NO signaling via the soluble guanyl cyclase-cyclic guanosine monophosphate-protein kinase G pathway, which together increase the free intracellular Ca2+ concentration along with the Ca2+ sensitivity of the myofilaments themselves.

Original languageEnglish
Pages (from-to)254-261
Number of pages8
JournalExercise and Sport Sciences Reviews
Issue number4
StatePublished - Oct 1 2018


  • calcium sensitivity
  • cyclic guanosine monophosphate
  • dietary nitrate
  • free intracellular calcium
  • muscle contractile function
  • nitric oxide
  • ryanodine receptor


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