TY - JOUR
T1 - Dietary glycaemic index, glycaemic load and head and neck cancer risk
T2 - a pooled analysis in an international consortium
AU - Chang, Chun Pin
AU - La Vecchia, Carlo
AU - Serraino, Diego
AU - Olshan, Andrew F.
AU - Zevallos, Jose P.
AU - Morgenstern, Hal
AU - Levi, Fabio
AU - Garavello, Werner
AU - Kelsey, Karl
AU - McClean, Michael
AU - Chen, Chu
AU - Schwartz, Stephen M.
AU - Schantz, Stimson
AU - Yu, Guo Pei
AU - Boffetta, Paolo
AU - Hashibe, Mia
AU - Lee, Yuan Chin Amy
AU - Parpinel, Maria
AU - Augustin, Livia S.A.
AU - Turati, Federica
AU - Zhang, Zuo Feng
AU - Edefonti, Valeria
N1 - Publisher Copyright:
© 2020, Cancer Research UK.
PY - 2020/3/17
Y1 - 2020/3/17
N2 - High dietary glycaemic index (GI) and glycaemic load (GL) may increase cancer risk. However, limited information was available on GI and/or GL and head and neck cancer (HNC) risk. We conducted a pooled analysis on 8 case-control studies (4081 HNC cases; 7407 controls) from the International Head and Neck Cancer Epidemiology (INHANCE) consortium. We estimated the odds ratios (ORs) and 95% confidence intervals (CIs) of HNC, and its subsites, from fixed- or mixed-effects logistic models including centre-specific quartiles of GI or GL. GI, but not GL, had a weak positive association with HNC (ORQ4 vs. Q1 = 1.16; 95% CI = 1.02–1.31). In subsites, we found a positive association between GI and laryngeal cancer (ORQ4 vs. Q1 = 1.60; 95% CI = 1.30–1.96) and an inverse association between GL and oropharyngeal cancer (ORQ4 vs. Q1 = 0.78; 95% CI = 0.63–0.97). This pooled analysis indicates a modest positive association between GI and HNC, mainly driven by laryngeal cancer.
AB - High dietary glycaemic index (GI) and glycaemic load (GL) may increase cancer risk. However, limited information was available on GI and/or GL and head and neck cancer (HNC) risk. We conducted a pooled analysis on 8 case-control studies (4081 HNC cases; 7407 controls) from the International Head and Neck Cancer Epidemiology (INHANCE) consortium. We estimated the odds ratios (ORs) and 95% confidence intervals (CIs) of HNC, and its subsites, from fixed- or mixed-effects logistic models including centre-specific quartiles of GI or GL. GI, but not GL, had a weak positive association with HNC (ORQ4 vs. Q1 = 1.16; 95% CI = 1.02–1.31). In subsites, we found a positive association between GI and laryngeal cancer (ORQ4 vs. Q1 = 1.60; 95% CI = 1.30–1.96) and an inverse association between GL and oropharyngeal cancer (ORQ4 vs. Q1 = 0.78; 95% CI = 0.63–0.97). This pooled analysis indicates a modest positive association between GI and HNC, mainly driven by laryngeal cancer.
UR - https://www.scopus.com/pages/publications/85077904082
U2 - 10.1038/s41416-019-0702-4
DO - 10.1038/s41416-019-0702-4
M3 - Article
C2 - 31929514
AN - SCOPUS:85077904082
SN - 0007-0920
VL - 122
SP - 745
EP - 748
JO - British Journal of Cancer
JF - British Journal of Cancer
IS - 6
ER -