TY - JOUR
T1 - Dietary fat intake and risk of ovarian cancer in the NIH-AARP Diet and Health Study
AU - Blank, M. M.
AU - Wentzensen, N.
AU - Murphy, M. A.
AU - Hollenbeck, A.
AU - Park, Y.
N1 - Funding Information:
Cancer incidence data from the Atlanta metropolitan area were collected by the Georgia Center for Cancer Statistics, Department of Epidemiology, Rollins School of Public Health, Emory University. Cancer incidence data from California were collected by the California Department of Health Services, Cancer Surveillance Section. Cancer incidence data from the Detroit metropolitan area were collected by the Michigan Cancer Surveillance Program, Community Health Administration, State of Michigan. The Florida cancer incidence data used in this report were collected by the Florida Cancer Data System (FCDC) under contract with the Florida Department of Health (FDOH). Cancer incidence data from Louisiana were collected by the Louisiana Tumor Registry, Louisiana State University Medical Center in New Orleans. Cancer incidence data from New Jersey were collected by the New Jersey State Cancer Registry, Cancer Epidemiology Services, New Jersey State Department of Health and Senior Services. Cancer incidence data from North Carolina were collected by the North Carolina Central Cancer Registry. Cancer incidence data from Pennsylvania were supplied by the Division of Health Statistics and Research, Pennsylvania Department of Health, Harrisburg, Pennsylvania. The Pennsylvania Department of Health specifically disclaims responsibility for any analyses, interpretations or conclusions. Cancer incidence data from Arizona were collected by the Arizona Cancer Registry, Division of Public Health Services, Arizona Department of Health Services. Cancer incidence data from Texas were collected by the Texas Cancer Registry, Cancer Epidemiology and Surveillance Branch, Texas Department of State Health Services. We are indebted to the participants in the NIH-AARP Diet and Health Study for their outstanding cooperation. We also thank Sigurd Hermansen and Kerry Grace Morrissey from Westat for study outcomes ascertainment and management and Leslie Carroll at Information Management Services for data support and analysis. We are deeply saddened by the loss of Dr Arthur Schatzkin, the principal investigator for the NIH-AARP Diet and Health Study, who passed away on 20 January 2011. The study was supported by the Intramural Research Program of the National Cancer Institute, National Institutes of Health. Megan A Murphy is supported in part by a training grant NIH 5 T32 CA09001–35.
PY - 2012/1/31
Y1 - 2012/1/31
N2 - Background: Fat intake has been postulated to increase risk of ovarian cancer, but previous studies have reported inconsistent results.Methods: The NIH-AARP Diet and Health Study, a large prospective cohort, assessed diet using a food frequency questionnaire at baseline in 1995-1996. During an average of 9 years of follow-up, 695 ovarian cancer cases were ascertained through the state cancer registry database. The relative risks (RRs) and 95% confidence interval (CI) were estimated using a Cox proportional hazard model. Results: Women in the highest vs the lowest quintile of total fat intake had a 28% increased risk of ovarian cancer (RR Q5 vs Q1 = 1.28, 95% CI: 1.01-1.63). Fat intake from animal sources (RR Q5 vs Q1 = 1.30; 95% CI: 1.02-1.66), but not from plant sources, was positively associated with ovarian cancer risk. Saturated and monounsaturated fat intakes were not related to risk of ovarian cancer, but polyunsaturated fat intake showed a weak positive association. The association between total fat intake and ovarian cancer was stronger in women who were nulliparous or never used oral contraceptives. Conclusion: Fat intake, especially from animal sources, was related to an increased risk of ovarian cancer. The association may be modified by parity and oral contraceptive use, which warrants further investigation.
AB - Background: Fat intake has been postulated to increase risk of ovarian cancer, but previous studies have reported inconsistent results.Methods: The NIH-AARP Diet and Health Study, a large prospective cohort, assessed diet using a food frequency questionnaire at baseline in 1995-1996. During an average of 9 years of follow-up, 695 ovarian cancer cases were ascertained through the state cancer registry database. The relative risks (RRs) and 95% confidence interval (CI) were estimated using a Cox proportional hazard model. Results: Women in the highest vs the lowest quintile of total fat intake had a 28% increased risk of ovarian cancer (RR Q5 vs Q1 = 1.28, 95% CI: 1.01-1.63). Fat intake from animal sources (RR Q5 vs Q1 = 1.30; 95% CI: 1.02-1.66), but not from plant sources, was positively associated with ovarian cancer risk. Saturated and monounsaturated fat intakes were not related to risk of ovarian cancer, but polyunsaturated fat intake showed a weak positive association. The association between total fat intake and ovarian cancer was stronger in women who were nulliparous or never used oral contraceptives. Conclusion: Fat intake, especially from animal sources, was related to an increased risk of ovarian cancer. The association may be modified by parity and oral contraceptive use, which warrants further investigation.
KW - Cohort studies
KW - Dietary fat
KW - Ovarian cancer
UR - http://www.scopus.com/inward/record.url?scp=84863042337&partnerID=8YFLogxK
U2 - 10.1038/bjc.2011.572
DO - 10.1038/bjc.2011.572
M3 - Article
C2 - 22223086
AN - SCOPUS:84863042337
SN - 0007-0920
VL - 106
SP - 596
EP - 602
JO - British Journal of Cancer
JF - British Journal of Cancer
IS - 3
ER -