TY - JOUR
T1 - Diet during Pregnancy and Infancy and the Infant Intestinal Microbiome
AU - Savage, Jessica H.
AU - Lee-Sarwar, Kathleen A.
AU - Sordillo, Joanne E.
AU - Lange, Nancy E.
AU - Zhou, Yanjiao
AU - O'Connor, George T.
AU - Sandel, Megan
AU - Bacharier, Leonard B.
AU - Zeiger, Robert
AU - Sodergren, Erica
AU - Weinstock, George M.
AU - Gold, Diane R.
AU - Weiss, Scott T.
AU - Litonjua, Augusto A.
N1 - Funding Information:
Supported by National Institutes of Health grant numbers R01HL091528, R01HL108818, K23AI110522, and 5T32AI007306-30. The authors declare no conflicts of interest.
Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2018/12
Y1 - 2018/12
N2 - Objectives: To determine the association between diet during pregnancy and infancy, including breastfeeding vs formula feeding, solid food introduction, and the infant intestinal microbiome. Study design: Infants participating in the Vitamin D Antenatal Asthma Reduction Trial were included in this study (n = 323). Maternal and infant diets were assessed by questionnaire. Infant stool samples were collected at age 3-6 months. Stool sequencing was performed using the Roche 454 platform. Analyses were stratified by race/ethnicity. Results: Breastfeeding, compared with formula feeding, was independently associated with infant intestinal microbial diversity. Breastfeeding also had the most consistent associations with individual taxa that have been previously linked to early-life diet and health outcomes (eg, Bifidobacterium). Maternal diet during pregnancy and solid food introduction were less associated with the infant gut microbiome than breastfeeding status. We found evidence of a possible interaction between breastfeeding and child race/ethnicity on microbial composition. Conclusions: Breastfeeding vs formula feeding is the dietary factor that is most consistently independently associated with the infant intestinal microbiome. The relationship between breastfeeding status and intestinal microbiome composition varies by child race/ethnicity. Future studies will need to investigate factors, including genomic factors, which may influence the response of the microbiome to diet. Trial registration: ClinicalTrials.gov: NCT00920621.
AB - Objectives: To determine the association between diet during pregnancy and infancy, including breastfeeding vs formula feeding, solid food introduction, and the infant intestinal microbiome. Study design: Infants participating in the Vitamin D Antenatal Asthma Reduction Trial were included in this study (n = 323). Maternal and infant diets were assessed by questionnaire. Infant stool samples were collected at age 3-6 months. Stool sequencing was performed using the Roche 454 platform. Analyses were stratified by race/ethnicity. Results: Breastfeeding, compared with formula feeding, was independently associated with infant intestinal microbial diversity. Breastfeeding also had the most consistent associations with individual taxa that have been previously linked to early-life diet and health outcomes (eg, Bifidobacterium). Maternal diet during pregnancy and solid food introduction were less associated with the infant gut microbiome than breastfeeding status. We found evidence of a possible interaction between breastfeeding and child race/ethnicity on microbial composition. Conclusions: Breastfeeding vs formula feeding is the dietary factor that is most consistently independently associated with the infant intestinal microbiome. The relationship between breastfeeding status and intestinal microbiome composition varies by child race/ethnicity. Future studies will need to investigate factors, including genomic factors, which may influence the response of the microbiome to diet. Trial registration: ClinicalTrials.gov: NCT00920621.
KW - breast milk
KW - formula
KW - solid food
UR - http://www.scopus.com/inward/record.url?scp=85054154124&partnerID=8YFLogxK
U2 - 10.1016/j.jpeds.2018.07.066
DO - 10.1016/j.jpeds.2018.07.066
M3 - Article
C2 - 30173873
AN - SCOPUS:85054154124
SN - 0022-3476
VL - 203
SP - 47-54.e4
JO - Journal of Pediatrics
JF - Journal of Pediatrics
ER -