Die Bedeutung von ICAM-1 auf die Lyse von humanen Pankreaskarzinomzellen durch autologe, zytotoxische T-Lymphozyten.

M. Peiper; P. S. Goedegebuure; T. J. Eberlein; C. E. Broelsch

Die Bedeutung von ICAM-1 auf die Lyse von humanen Pankreaskarzinomzellen durch autologe, zytotoxische T-Lymphozyten.

Translated title of the contribution: Significance if ICAM-1 on lysis of human pancreatic carcinoma cells by autologous, cytotoxic T-lymphocytes

M. Peiper, P. S. Goedegebuure, T. J. Eberlein, C. E. Broelsch

Research output: Contribution to journal › Article › peer-review

Abstract

Cytotoxic T-Lymphocytes were generated from tumor-infiltrating lymphocytes of a newly established pancreatic cancer cell line, which lysed autologous tumor cells significantly and HLA-class I restricted. ICAM-1+ tumor clones were significantly higher lysed than an ICAM-1- clone. Stimulation with IFN-gamma resulted in a higher expression of ICAM-1 and significantly higher lysis, which was inhibited by anti-ICAM-1 monoclonal antibodies.

Translated title of the contribution	Significance if ICAM-1 on lysis of human pancreatic carcinoma cells by autologous, cytotoxic T-lymphocytes
Original language	German
Pages (from-to)	59-62
Number of pages	4
Journal	Langenbecks Archiv für Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft für Chirurgie. Kongress
Volume	115
Issue number	Suppl I
State	Published - 1998

Cite this

@article{0c2c49c7aa124d128dfbc4eb6993df4c,

title = "Die Bedeutung von ICAM-1 auf die Lyse von humanen Pankreaskarzinomzellen durch autologe, zytotoxische T-Lymphozyten.",

abstract = "Cytotoxic T-Lymphocytes were generated from tumor-infiltrating lymphocytes of a newly established pancreatic cancer cell line, which lysed autologous tumor cells significantly and HLA-class I restricted. ICAM-1+ tumor clones were significantly higher lysed than an ICAM-1- clone. Stimulation with IFN-gamma resulted in a higher expression of ICAM-1 and significantly higher lysis, which was inhibited by anti-ICAM-1 monoclonal antibodies.",

author = "M. Peiper and Goedegebuure, {P. S.} and Eberlein, {T. J.} and Broelsch, {C. E.}",

year = "1998",

language = "German",

volume = "115",

pages = "59--62",

journal = "Langenbecks Archiv f{\"u}r Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft f{\"u}r Chirurgie. Kongress",

issn = "0942-2854",

number = "Suppl I",

}

Die Bedeutung von ICAM-1 auf die Lyse von humanen Pankreaskarzinomzellen durch autologe, zytotoxische T-Lymphozyten. / Peiper, M.; Goedegebuure, P. S.; Eberlein, T. J. et al.
In: Langenbecks Archiv für Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft für Chirurgie. Kongress, Vol. 115, No. Suppl I, 1998, p. 59-62.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Die Bedeutung von ICAM-1 auf die Lyse von humanen Pankreaskarzinomzellen durch autologe, zytotoxische T-Lymphozyten.

AU - Peiper, M.

AU - Goedegebuure, P. S.

AU - Eberlein, T. J.

AU - Broelsch, C. E.

PY - 1998

Y1 - 1998

N2 - Cytotoxic T-Lymphocytes were generated from tumor-infiltrating lymphocytes of a newly established pancreatic cancer cell line, which lysed autologous tumor cells significantly and HLA-class I restricted. ICAM-1+ tumor clones were significantly higher lysed than an ICAM-1- clone. Stimulation with IFN-gamma resulted in a higher expression of ICAM-1 and significantly higher lysis, which was inhibited by anti-ICAM-1 monoclonal antibodies.

AB - Cytotoxic T-Lymphocytes were generated from tumor-infiltrating lymphocytes of a newly established pancreatic cancer cell line, which lysed autologous tumor cells significantly and HLA-class I restricted. ICAM-1+ tumor clones were significantly higher lysed than an ICAM-1- clone. Stimulation with IFN-gamma resulted in a higher expression of ICAM-1 and significantly higher lysis, which was inhibited by anti-ICAM-1 monoclonal antibodies.

UR - http://www.scopus.com/inward/record.url?scp=0142217852&partnerID=8YFLogxK

M3 - Article

C2 - 14518213

AN - SCOPUS:0142217852

SN - 0942-2854

VL - 115

SP - 59

EP - 62

JO - Langenbecks Archiv für Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft für Chirurgie. Kongress

JF - Langenbecks Archiv für Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft für Chirurgie. Kongress

IS - Suppl I

ER -

Die Bedeutung von ICAM-1 auf die Lyse von humanen Pankreaskarzinomzellen durch autologe, zytotoxische T-Lymphozyten.

Abstract

Other files and links

Fingerprint

Cite this