Dicarboxylic acids as pH sensors for hyperpolarized 13C magnetic resonance spectroscopic imaging

D. E. Korenchan; C. Taglang; C. Von Morze; J. E. Blecha; J. W. Gordon; R. Sriram; P. E.Z. Larson; D. B. Vigneron; H. F. Vanbrocklin; J. Kurhanewicz; D. M. Wilson; R. R. Flavell

doi:10.1039/c7an00076f

Dicarboxylic acids as pH sensors for hyperpolarized ¹³C magnetic resonance spectroscopic imaging

D. E. Korenchan
, C. Taglang
, C. Von Morze
, J. E. Blecha
, J. W. Gordon
, R. Sriram
, P. E.Z. Larson
, D. B. Vigneron
, H. F. Vanbrocklin
, J. Kurhanewicz
, D. M. Wilson
, R. R. Flavell

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Imaging tumoral pH may help to characterize aggressiveness, metastasis, and therapeutic response. We report the development of hyperpolarized [2-¹³C,D₁₀]diethylmalonic acid, which exhibits a large pH-dependent ¹³C chemical shift over the physiological range. We demonstrate that co-polarization with [1-¹³C,D₉]tert-butanol accurately measures pH via¹³C NMR and magnetic resonance spectroscopic imaging in phantoms.

Original language	English
Pages (from-to)	1429-1433
Number of pages	5
Journal	Analyst
Volume	142
Issue number	9
DOIs	https://doi.org/10.1039/c7an00076f
State	Published - May 7 2017

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@article{ec290280d4b2491ebd8853167258b952,

title = "Dicarboxylic acids as pH sensors for hyperpolarized 13C magnetic resonance spectroscopic imaging",

abstract = "Imaging tumoral pH may help to characterize aggressiveness, metastasis, and therapeutic response. We report the development of hyperpolarized [2-13C,D10]diethylmalonic acid, which exhibits a large pH-dependent 13C chemical shift over the physiological range. We demonstrate that co-polarization with [1-13C,D9]tert-butanol accurately measures pH via13C NMR and magnetic resonance spectroscopic imaging in phantoms.",

author = "Korenchan, \{D. E.\} and C. Taglang and \{Von Morze\}, C. and Blecha, \{J. E.\} and Gordon, \{J. W.\} and R. Sriram and Larson, \{P. E.Z.\} and Vigneron, \{D. B.\} and Vanbrocklin, \{H. F.\} and J. Kurhanewicz and Wilson, \{D. M.\} and Flavell, \{R. R.\}",

note = "Publisher Copyright: {\textcopyright} 2017 The Royal Society of Chemistry.",

year = "2017",

month = may,

day = "7",

doi = "10.1039/c7an00076f",

language = "English",

volume = "142",

pages = "1429--1433",

journal = "Analyst",

issn = "0003-2654",

number = "9",

}

TY - JOUR

T1 - Dicarboxylic acids as pH sensors for hyperpolarized 13C magnetic resonance spectroscopic imaging

AU - Korenchan, D. E.

AU - Taglang, C.

AU - Von Morze, C.

AU - Blecha, J. E.

AU - Gordon, J. W.

AU - Sriram, R.

AU - Larson, P. E.Z.

AU - Vigneron, D. B.

AU - Vanbrocklin, H. F.

AU - Kurhanewicz, J.

AU - Wilson, D. M.

AU - Flavell, R. R.

PY - 2017/5/7

Y1 - 2017/5/7

N2 - Imaging tumoral pH may help to characterize aggressiveness, metastasis, and therapeutic response. We report the development of hyperpolarized [2-13C,D10]diethylmalonic acid, which exhibits a large pH-dependent 13C chemical shift over the physiological range. We demonstrate that co-polarization with [1-13C,D9]tert-butanol accurately measures pH via13C NMR and magnetic resonance spectroscopic imaging in phantoms.

AB - Imaging tumoral pH may help to characterize aggressiveness, metastasis, and therapeutic response. We report the development of hyperpolarized [2-13C,D10]diethylmalonic acid, which exhibits a large pH-dependent 13C chemical shift over the physiological range. We demonstrate that co-polarization with [1-13C,D9]tert-butanol accurately measures pH via13C NMR and magnetic resonance spectroscopic imaging in phantoms.

UR - https://www.scopus.com/pages/publications/85021757137

U2 - 10.1039/c7an00076f

DO - 10.1039/c7an00076f

M3 - Article

C2 - 28322385

AN - SCOPUS:85021757137

SN - 0003-2654

VL - 142

SP - 1429

EP - 1433

JO - Analyst

JF - Analyst

IS - 9

ER -

Dicarboxylic acids as pH sensors for hyperpolarized ¹³C magnetic resonance spectroscopic imaging

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