Dicarboxylic acids as pH sensors for hyperpolarized 13C magnetic resonance spectroscopic imaging

D. E. Korenchan; C. Taglang; C. Von Morze; J. E. Blecha; J. W. Gordon; R. Sriram; P. E.Z. Larson; D. B. Vigneron; H. F. Vanbrocklin; J. Kurhanewicz; D. M. Wilson; R. R. Flavell

doi:10.1039/c7an00076f

Dicarboxylic acids as pH sensors for hyperpolarized ¹³C magnetic resonance spectroscopic imaging

D. E. Korenchan, C. Taglang, C. Von Morze, J. E. Blecha, J. W. Gordon, R. Sriram, P. E.Z. Larson, D. B. Vigneron, H. F. Vanbrocklin, J. Kurhanewicz, D. M. Wilson, R. R. Flavell

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26 Scopus citations

Abstract

Imaging tumoral pH may help to characterize aggressiveness, metastasis, and therapeutic response. We report the development of hyperpolarized [2-¹³C,D₁₀]diethylmalonic acid, which exhibits a large pH-dependent ¹³C chemical shift over the physiological range. We demonstrate that co-polarization with [1-¹³C,D₉]tert-butanol accurately measures pH via¹³C NMR and magnetic resonance spectroscopic imaging in phantoms.

Original language	English
Pages (from-to)	1429-1433
Number of pages	5
Journal	Analyst
Volume	142
Issue number	9
DOIs	https://doi.org/10.1039/c7an00076f
State	Published - May 7 2017

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title = "Dicarboxylic acids as pH sensors for hyperpolarized 13C magnetic resonance spectroscopic imaging",

abstract = "Imaging tumoral pH may help to characterize aggressiveness, metastasis, and therapeutic response. We report the development of hyperpolarized [2-13C,D10]diethylmalonic acid, which exhibits a large pH-dependent 13C chemical shift over the physiological range. We demonstrate that co-polarization with [1-13C,D9]tert-butanol accurately measures pH via13C NMR and magnetic resonance spectroscopic imaging in phantoms.",

author = "Korenchan, {D. E.} and C. Taglang and {Von Morze}, C. and Blecha, {J. E.} and Gordon, {J. W.} and R. Sriram and Larson, {P. E.Z.} and Vigneron, {D. B.} and Vanbrocklin, {H. F.} and J. Kurhanewicz and Wilson, {D. M.} and Flavell, {R. R.}",

note = "Publisher Copyright: {\textcopyright} 2017 The Royal Society of Chemistry.",

year = "2017",

month = may,

day = "7",

doi = "10.1039/c7an00076f",

language = "English",

volume = "142",

pages = "1429--1433",

journal = "Analyst",

issn = "0003-2654",

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TY - JOUR

T1 - Dicarboxylic acids as pH sensors for hyperpolarized 13C magnetic resonance spectroscopic imaging

AU - Korenchan, D. E.

AU - Taglang, C.

AU - Von Morze, C.

AU - Blecha, J. E.

AU - Gordon, J. W.

AU - Sriram, R.

AU - Larson, P. E.Z.

AU - Vigneron, D. B.

AU - Vanbrocklin, H. F.

AU - Kurhanewicz, J.

AU - Wilson, D. M.

AU - Flavell, R. R.

PY - 2017/5/7

Y1 - 2017/5/7

N2 - Imaging tumoral pH may help to characterize aggressiveness, metastasis, and therapeutic response. We report the development of hyperpolarized [2-13C,D10]diethylmalonic acid, which exhibits a large pH-dependent 13C chemical shift over the physiological range. We demonstrate that co-polarization with [1-13C,D9]tert-butanol accurately measures pH via13C NMR and magnetic resonance spectroscopic imaging in phantoms.

AB - Imaging tumoral pH may help to characterize aggressiveness, metastasis, and therapeutic response. We report the development of hyperpolarized [2-13C,D10]diethylmalonic acid, which exhibits a large pH-dependent 13C chemical shift over the physiological range. We demonstrate that co-polarization with [1-13C,D9]tert-butanol accurately measures pH via13C NMR and magnetic resonance spectroscopic imaging in phantoms.

UR - http://www.scopus.com/inward/record.url?scp=85021757137&partnerID=8YFLogxK

U2 - 10.1039/c7an00076f

DO - 10.1039/c7an00076f

M3 - Article

C2 - 28322385

AN - SCOPUS:85021757137

SN - 0003-2654

VL - 142

SP - 1429

EP - 1433

JO - Analyst

JF - Analyst

IS - 9

ER -

Dicarboxylic acids as pH sensors for hyperpolarized ¹³C magnetic resonance spectroscopic imaging

Abstract

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