@article{ec290280d4b2491ebd8853167258b952,
title = "Dicarboxylic acids as pH sensors for hyperpolarized 13C magnetic resonance spectroscopic imaging",
abstract = "Imaging tumoral pH may help to characterize aggressiveness, metastasis, and therapeutic response. We report the development of hyperpolarized [2-13C,D10]diethylmalonic acid, which exhibits a large pH-dependent 13C chemical shift over the physiological range. We demonstrate that co-polarization with [1-13C,D9]tert-butanol accurately measures pH via13C NMR and magnetic resonance spectroscopic imaging in phantoms.",
author = "Korenchan, {D. E.} and C. Taglang and {Von Morze}, C. and Blecha, {J. E.} and Gordon, {J. W.} and R. Sriram and Larson, {P. E.Z.} and Vigneron, {D. B.} and Vanbrocklin, {H. F.} and J. Kurhanewicz and Wilson, {D. M.} and Flavell, {R. R.}",
note = "Funding Information: This research was supported by the National Institutes of Health (R01-CA166766), the Education and Research Foundation for Nuclear Medicine and Molecular Imaging (SNMMI-ERF Mitzi and William Blahd, MD, Pilot Grant), the Radiological Society of North America (RSNA Research Fellow Grant), and the Department of Defense (Physician Research Training Grant PC150932). Publisher Copyright: {\textcopyright} 2017 The Royal Society of Chemistry.",
year = "2017",
month = may,
day = "7",
doi = "10.1039/c7an00076f",
language = "English",
volume = "142",
pages = "1429--1433",
journal = "Analyst",
issn = "0003-2654",
number = "9",
}