Diazepam-induced amnesia: A neuropharmacological model of an 'organic amnestic syndrome'

O. M. Wolkowitz, H. Weingartner, K. Thompson, D. Pickar, S. M. Paul, D. W. Hommer

Research output: Contribution to journalArticle

62 Scopus citations

Abstract

Diazepam has well-known amnestic properties. These effects, however, are selective for certain psychobiologically distinct memory functions. In this study, incremental doses of diazepam administered to 10 normal volunteers selectively impaired anterograde episodic memory and attention while totally sparing access to information in long-term memory (semantic or knowledge memory). This pattern of disruption mimics that seen in patients with organic amnesias and is in sharp contrast to the pattern seen in patients with dementia. These findings provide a framework for defining specific psychobiological determinants of cognitive failure.

Original languageEnglish
Pages (from-to)25-29
Number of pages5
JournalAmerican Journal of Psychiatry
Volume144
Issue number1
DOIs
StatePublished - Jan 1 1987
Externally publishedYes

Fingerprint Dive into the research topics of 'Diazepam-induced amnesia: A neuropharmacological model of an 'organic amnestic syndrome''. Together they form a unique fingerprint.

  • Cite this