TY - JOUR
T1 - Diagnostic Utility of Selective Upper Tract Urinary Cytology
T2 - A Systematic Review and Meta-analysis of the Literature
AU - Potretzke, Aaron M.
AU - Knight, B. Alexander
AU - Vetter, Joel M.
AU - Anderson, Barrett G.
AU - Hardi, Angela C.
AU - Bhayani, Sam B.
AU - Figenshau, R. Sherburne
N1 - Publisher Copyright:
© 2016 Elsevier Inc.
PY - 2016/10/1
Y1 - 2016/10/1
N2 - The diagnosis of upper tract urothelial carcinoma (UTUC) can be a challenging diagnostic pursuit. To date, there is no large-scale study assessing the statistical utility (eg, sensitivity and specificity) of selective cytology. Herein, we systematically reviewed and meta-analyzed the published literature to evaluate the efficacy of selective cytology for the detection of UTUC in patients with a suspicious clinical profile Selective cytology confers a high specificity but marginal sensitivity for the detection of UTUC. The sensitivity is greater for high-grade UTUC lesions. The statistical assessment of its utility is limited by the heterogeneity and bias of previous studies.
AB - The diagnosis of upper tract urothelial carcinoma (UTUC) can be a challenging diagnostic pursuit. To date, there is no large-scale study assessing the statistical utility (eg, sensitivity and specificity) of selective cytology. Herein, we systematically reviewed and meta-analyzed the published literature to evaluate the efficacy of selective cytology for the detection of UTUC in patients with a suspicious clinical profile Selective cytology confers a high specificity but marginal sensitivity for the detection of UTUC. The sensitivity is greater for high-grade UTUC lesions. The statistical assessment of its utility is limited by the heterogeneity and bias of previous studies.
UR - http://www.scopus.com/inward/record.url?scp=84973891578&partnerID=8YFLogxK
U2 - 10.1016/j.urology.2016.04.030
DO - 10.1016/j.urology.2016.04.030
M3 - Review article
C2 - 27151340
AN - SCOPUS:84973891578
SN - 0090-4295
VL - 96
SP - 35
EP - 43
JO - Urology
JF - Urology
ER -