Diagnostic potential for miRNAs as biomarkers for pregnancy-specific diseases

Zhen Zhao, Kelle H. Moley, Ann M. Gronowski

Research output: Contribution to journalReview articlepeer-review

84 Scopus citations

Abstract

Discovery of circulating miRNAs in maternal blood has not only facilitated the understanding of their role in normal pregnancy, but also paved new avenues for biomarker discovery to detect pregnancy-associated complications, such as preeclampsia, ectopic pregnancy, gestational diabetes mellitus, fetal growth restriction, recurrent pregnancy loss, and preterm delivery. In this review, we summarize the studies to date of miRNAs in maternal circulation and placental tissue in human. This brief review does not cover all aspects of this intriguing field but focuses on some new and interesting findings of diagnostic potential for miRNAs as biomarkers for pregnancy-specific diseases.

Original languageEnglish
Pages (from-to)953-960
Number of pages8
JournalClinical Biochemistry
Volume46
Issue number10-11
DOIs
StatePublished - Jul 2013

Keywords

  • Biomarker
  • MiRNA
  • Pregnancy

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