TY - JOUR
T1 - Diagnostic criteria for Alzheimer's disease
AU - Price, J. L.
N1 - Funding Information:
I thank Mr. Hieu Van Luu, Ms. Melissa Rundle, Mr. David Wavek, and Mr. Karan Randhava for their excellent technical assistance. This work was supported by Grant P01 AG03991 from the United States Public Health Service/National Institute on Aging.
PY - 1997
Y1 - 1997
N2 - This paper summarizes changes that distinguish early Alzheimer's disease (AD) from nondemented aging based on 49 well characterized cases (30 nondemented, 10 very mildly demented, and 9 severely demented). Tangles were found in all nondemented cases (aged 54 to 88) concentrated in limbic structures. The probability of high tangle density increases with age, even in the absence of plaques or dementia. Based on plaques, nondemented cases can be divided into three groups: 1) cases younger than 73 years of age with one-third of older cases had no plaques; 2) about one-half of cases over 74 years of age had a few diffuse plaques in restricted patches in the neocortex; 3) about one-quarter of cases over 74 years of age had many neuritic and diffuse plaques throughout the neocortex; these may represent 'preclinical' AD. Very mildly demented cases had high concentrations of neuritic and diffuse plaques in the neocortex and tangles in limbic structures. The observations indicate that the minimal diagnostic criterion for AD is plaques throughout the neocortex together with neurofibrillary changes (tangles in limbic structures and neuritic plaques in cortex). Tangles are a necessary but not sufficient criterion.
AB - This paper summarizes changes that distinguish early Alzheimer's disease (AD) from nondemented aging based on 49 well characterized cases (30 nondemented, 10 very mildly demented, and 9 severely demented). Tangles were found in all nondemented cases (aged 54 to 88) concentrated in limbic structures. The probability of high tangle density increases with age, even in the absence of plaques or dementia. Based on plaques, nondemented cases can be divided into three groups: 1) cases younger than 73 years of age with one-third of older cases had no plaques; 2) about one-half of cases over 74 years of age had a few diffuse plaques in restricted patches in the neocortex; 3) about one-quarter of cases over 74 years of age had many neuritic and diffuse plaques throughout the neocortex; these may represent 'preclinical' AD. Very mildly demented cases had high concentrations of neuritic and diffuse plaques in the neocortex and tangles in limbic structures. The observations indicate that the minimal diagnostic criterion for AD is plaques throughout the neocortex together with neurofibrillary changes (tangles in limbic structures and neuritic plaques in cortex). Tangles are a necessary but not sufficient criterion.
KW - Aging
KW - Clinical dementia rating
KW - Plaques
KW - Pre-clinical Alzheimer's disease
KW - Tangles
UR - http://www.scopus.com/inward/record.url?scp=0030681218&partnerID=8YFLogxK
U2 - 10.1016/S0197-4580(97)00072-9
DO - 10.1016/S0197-4580(97)00072-9
M3 - Article
C2 - 9330988
AN - SCOPUS:0030681218
SN - 0197-4580
VL - 18
SP - S67-S70
JO - Neurobiology of Aging
JF - Neurobiology of Aging
IS - 4 SUPPL.
ER -