TY - JOUR
T1 - Diagnostic and therapeutic strategies for small abdominal aortic aneurysms
AU - Klink, Ahmed
AU - Hyafil, Fabien
AU - Rudd, James
AU - Faries, Peter
AU - Fuster, Valentin
AU - Mallat, Ziad
AU - Meilhac, Olivier
AU - Mulder, Willem J.M.
AU - Michel, Jean Baptiste
AU - Ramirez, Francesco
AU - Storm, Gert
AU - Thompson, Robert
AU - Turnbull, Irene C.
AU - Egido, Jesus
AU - Martín-Ventura, Jose L.
AU - Zaragoza, Carlos
AU - Letourneur, Didier
AU - Fayad, Zahi A.
PY - 2011/6
Y1 - 2011/6
N2 - Abdominal aortic aneurysms (AAA) affect 5% of the population in developed countries and are characterized by progressive aortic dilatation with an unpredictable time course. This condition is more common in men than in women, and in smokers than in nonsmokers. If left untreated, AAA can result in aortic rupture and death. Pathologically, aortic extracellular matrix degradation, inflammation, and neovascularization are hallmarks of AAA. Diagnosis of AAA and subsequent surveillance utilize established aortic imaging methods, such as ultrasound, CT, and MRI. More-speculative diagnostic approaches include molecular and cellular imaging methods that interrogate the underlying pathological processes at work within the aneurysm. In this Review, we explore the current diagnostic and therapeutic strategies for the management of AAA. We also describe the diagnostic potential of new imaging techniques and therapeutic potential of new treatments for the management of small AAA.
AB - Abdominal aortic aneurysms (AAA) affect 5% of the population in developed countries and are characterized by progressive aortic dilatation with an unpredictable time course. This condition is more common in men than in women, and in smokers than in nonsmokers. If left untreated, AAA can result in aortic rupture and death. Pathologically, aortic extracellular matrix degradation, inflammation, and neovascularization are hallmarks of AAA. Diagnosis of AAA and subsequent surveillance utilize established aortic imaging methods, such as ultrasound, CT, and MRI. More-speculative diagnostic approaches include molecular and cellular imaging methods that interrogate the underlying pathological processes at work within the aneurysm. In this Review, we explore the current diagnostic and therapeutic strategies for the management of AAA. We also describe the diagnostic potential of new imaging techniques and therapeutic potential of new treatments for the management of small AAA.
UR - http://www.scopus.com/inward/record.url?scp=79957839382&partnerID=8YFLogxK
U2 - 10.1038/nrcardio.2011.1
DO - 10.1038/nrcardio.2011.1
M3 - Review article
C2 - 21304473
AN - SCOPUS:79957839382
SN - 1759-5002
VL - 8
SP - 338
EP - 347
JO - Nature Reviews Cardiology
JF - Nature Reviews Cardiology
IS - 6
ER -