Diabetes Resistant to Subcutaneous Insulin: Effect of Aprotinin

J. C. Pickup; G. Williams; R. W. Bilous; H. Keen; Stephen Colagiuri; Harry Grunstein; M. Berger; R. I. Misbin; W. C. Duckworth; R. E. Offord; P. A. Halban; J. Philippe; Gary R. Freidenberg; Juan F. Sotos; Neil White; Julio V. Santiago; Samuel Cataland; Thomas M. O'dorisio

doi:10.1056/NEJM198112033052313

Diabetes Resistant to Subcutaneous Insulin: Effect of Aprotinin

J. C. Pickup, G. Williams, R. W. Bilous, H. Keen, Stephen Colagiuri, Harry Grunstein, M. Berger, R. I. Misbin, W. C. Duckworth, R. E. Offord, P. A. Halban, J. Philippe, Gary R. Freidenberg, Juan F. Sotos, Neil White, Julio V. Santiago, Samuel Cataland, Thomas M. O'dorisio

Research output: Contribution to journal › Letter › peer-review

4 Scopus citations

Abstract

To the Editor: We have reported on a group of exceptionally“brittle”diabetics whose clinical features resemble those of the patients described by Dr. Freidenberg and his colleagues in the August 13 issue.¹ All the patients are female; in many the disease is not controlled by doses of more than 100 units of insulin a day, injected or infused subcutaneously. Near normoglycemia is restored by continuous intramuscular infusion of insulin,² which presumably bypasses a barrier to subcutaneous absorption. Recently, we measured the breakdown of Radio-labeled and native insulin by subcutaneous-tissue biopsy specimens. The rate of insulin degradation in vitro by. . .

Original language	English
Pages (from-to)	1413-1414
Number of pages	2
Journal	New England Journal of Medicine
Volume	305
Issue number	23
DOIs	https://doi.org/10.1056/NEJM198112033052313
State	Published - Dec 3 1981

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Pickup, J. C., Williams, G., Bilous, R. W., Keen, H., Colagiuri, S., Grunstein, H., Berger, M., Misbin, R. I., Duckworth, W. C., Offord, R. E., Halban, P. A., Philippe, J., Freidenberg, G. R., Sotos, J. F., White, N., Santiago, J. V., Cataland, S., & O'dorisio, T. M. (1981). Diabetes Resistant to Subcutaneous Insulin: Effect of Aprotinin. New England Journal of Medicine, 305(23), 1413-1414. https://doi.org/10.1056/NEJM198112033052313

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title = "Diabetes Resistant to Subcutaneous Insulin: Effect of Aprotinin",

abstract = "To the Editor: We have reported on a group of exceptionally“brittle”diabetics whose clinical features resemble those of the patients described by Dr. Freidenberg and his colleagues in the August 13 issue.1 All the patients are female; in many the disease is not controlled by doses of more than 100 units of insulin a day, injected or infused subcutaneously. Near normoglycemia is restored by continuous intramuscular infusion of insulin,2 which presumably bypasses a barrier to subcutaneous absorption. Recently, we measured the breakdown of Radio-labeled and native insulin by subcutaneous-tissue biopsy specimens. The rate of insulin degradation in vitro by. . .",

author = "Pickup, {J. C.} and G. Williams and Bilous, {R. W.} and H. Keen and Stephen Colagiuri and Harry Grunstein and M. Berger and Misbin, {R. I.} and Duckworth, {W. C.} and Offord, {R. E.} and Halban, {P. A.} and J. Philippe and Freidenberg, {Gary R.} and Sotos, {Juan F.} and Neil White and Santiago, {Julio V.} and Samuel Cataland and O'dorisio, {Thomas M.}",

year = "1981",

month = dec,

day = "3",

doi = "10.1056/NEJM198112033052313",

language = "English",

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Pickup, JC, Williams, G, Bilous, RW, Keen, H, Colagiuri, S, Grunstein, H, Berger, M, Misbin, RI, Duckworth, WC, Offord, RE, Halban, PA, Philippe, J, Freidenberg, GR, Sotos, JF, White, N, Santiago, JV, Cataland, S & O'dorisio, TM 1981, 'Diabetes Resistant to Subcutaneous Insulin: Effect of Aprotinin', New England Journal of Medicine, vol. 305, no. 23, pp. 1413-1414. https://doi.org/10.1056/NEJM198112033052313

TY - JOUR

T1 - Diabetes Resistant to Subcutaneous Insulin

T2 - Effect of Aprotinin

AU - Pickup, J. C.

AU - Williams, G.

AU - Bilous, R. W.

AU - Keen, H.

AU - Colagiuri, Stephen

AU - Grunstein, Harry

AU - Berger, M.

AU - Misbin, R. I.

AU - Duckworth, W. C.

AU - Offord, R. E.

AU - Halban, P. A.

AU - Philippe, J.

AU - Freidenberg, Gary R.

AU - Sotos, Juan F.

AU - White, Neil

AU - Santiago, Julio V.

AU - Cataland, Samuel

AU - O'dorisio, Thomas M.

PY - 1981/12/3

Y1 - 1981/12/3

N2 - To the Editor: We have reported on a group of exceptionally“brittle”diabetics whose clinical features resemble those of the patients described by Dr. Freidenberg and his colleagues in the August 13 issue.1 All the patients are female; in many the disease is not controlled by doses of more than 100 units of insulin a day, injected or infused subcutaneously. Near normoglycemia is restored by continuous intramuscular infusion of insulin,2 which presumably bypasses a barrier to subcutaneous absorption. Recently, we measured the breakdown of Radio-labeled and native insulin by subcutaneous-tissue biopsy specimens. The rate of insulin degradation in vitro by. . .

AB - To the Editor: We have reported on a group of exceptionally“brittle”diabetics whose clinical features resemble those of the patients described by Dr. Freidenberg and his colleagues in the August 13 issue.1 All the patients are female; in many the disease is not controlled by doses of more than 100 units of insulin a day, injected or infused subcutaneously. Near normoglycemia is restored by continuous intramuscular infusion of insulin,2 which presumably bypasses a barrier to subcutaneous absorption. Recently, we measured the breakdown of Radio-labeled and native insulin by subcutaneous-tissue biopsy specimens. The rate of insulin degradation in vitro by. . .

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U2 - 10.1056/NEJM198112033052313

DO - 10.1056/NEJM198112033052313

M3 - Letter

C2 - 6170889

AN - SCOPUS:0019793011

SN - 0028-4793

VL - 305

SP - 1413

EP - 1414

JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 23

ER -

Diabetes Resistant to Subcutaneous Insulin: Effect of Aprotinin

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