TY - JOUR
T1 - Diabetes decreases FDG accumulation in primary lung cancer
AU - Torizuka, Tatsuo
AU - Zasadny, Kenneth R.
AU - Wahl, Richard L.
N1 - Funding Information:
Grants CA52880, CA53172, and CA56731, awarded by the National Cancer Institute.
PY - 1999
Y1 - 1999
N2 - Objective: To compare kinetics and accumulation of 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (FDG) in primary lung cancer between diabetic and non-diabetic patients using positron emission tomography (PET). Methods: Five diabetic patients and 21 non-diabetic patients underwent dynamic FDG-PET to image untreated primary lung cancers. Standardized uptake value normalized for lean body mass (SUL) was determined in tumor, blood, muscle, and lung. A 3-compartment metabolic model was applied to FDG kinetics in tumors in 24 of 26 patients. Results: At the time of PET scans, serum glucose levels were elevated in 5 diabetic patients, while 21 non-diabetic patients showed normal glucose levels. In diabetic patients, tumor SUL, tumor/blood and rumor/muscle SUL ratios were significantly decreased (P < 0.02) and also rumor/lung SUL ratio declined (P = 0.064), as compared to non-diabetic patients. In addition, the rate constant for FDG phosphorylation (k3) and influx constant (Ki) in diabetic patients were significantly lower than those in non-diabetic patients (P < 0.02). Conclusion: In diabetic patients, the rate of FDG accumulation in tumors is decreased, and tumor targeting with FDG is impaired. Diabetes may reduce the sensitivity of FDG-PET for lung cancer detection.
AB - Objective: To compare kinetics and accumulation of 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (FDG) in primary lung cancer between diabetic and non-diabetic patients using positron emission tomography (PET). Methods: Five diabetic patients and 21 non-diabetic patients underwent dynamic FDG-PET to image untreated primary lung cancers. Standardized uptake value normalized for lean body mass (SUL) was determined in tumor, blood, muscle, and lung. A 3-compartment metabolic model was applied to FDG kinetics in tumors in 24 of 26 patients. Results: At the time of PET scans, serum glucose levels were elevated in 5 diabetic patients, while 21 non-diabetic patients showed normal glucose levels. In diabetic patients, tumor SUL, tumor/blood and rumor/muscle SUL ratios were significantly decreased (P < 0.02) and also rumor/lung SUL ratio declined (P = 0.064), as compared to non-diabetic patients. In addition, the rate constant for FDG phosphorylation (k3) and influx constant (Ki) in diabetic patients were significantly lower than those in non-diabetic patients (P < 0.02). Conclusion: In diabetic patients, the rate of FDG accumulation in tumors is decreased, and tumor targeting with FDG is impaired. Diabetes may reduce the sensitivity of FDG-PET for lung cancer detection.
KW - Diabetes
KW - FDG-PET
KW - Lung Cancer
UR - http://www.scopus.com/inward/record.url?scp=0141940520&partnerID=8YFLogxK
U2 - 10.1016/S1095-0397(99)00029-1
DO - 10.1016/S1095-0397(99)00029-1
M3 - Article
AN - SCOPUS:0141940520
SN - 1095-0397
VL - 2
SP - 281
EP - 287
JO - Clinical Positron Imaging (Netherlands)
JF - Clinical Positron Imaging (Netherlands)
IS - 5
ER -