Dexterous robotic manipulation of alert adult Drosophila for high-content experimentation

Joan Savall; Eric Tatt Wei Ho; Cheng Huang; Jessica R. Maxey; Mark J. Schnitzer

doi:10.1038/nmeth.3410

Dexterous robotic manipulation of alert adult Drosophila for high-content experimentation

Joan Savall, Eric Tatt Wei Ho, Cheng Huang, Jessica R. Maxey, Mark J. Schnitzer

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

We present a robot that enables high-content studies of alert adult Drosophila by combining operations including gentle picking; translations and rotations; characterizations of fly phenotypes and behaviors; microdissection; or release. To illustrate, we assessed fly morphology, tracked odor-evoked locomotion, sorted flies by sex, and dissected the cuticle to image neural activity. The robot's tireless capacity for precise manipulations enables a scalable platform for screening flies' complex attributes and behavioral patterns.

Original language	English
Pages (from-to)	657-660
Number of pages	4
Journal	Nature Methods
Volume	12
Issue number	7
DOIs	https://doi.org/10.1038/nmeth.3410
State	Published - Jun 30 2015

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Dexterous robotic manipulation of alert adult Drosophila for high-content experimentation

Abstract

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