Dexamethasone therapy of triethyltin induced cerebral edema

Rebecca K. Studer, Barry A. Siegel, Janet Morgan, E. James Potchen

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


After administration of 1.25 mg/kg triethyltin bromide daily to rats for 7 days, cerebral edema results characterized by increased brain water and sodium, normal brain potassium, decreased cerebral blood volume, and without evidence for increased microvascular permeability to albumin and pertechnetate. Concurrent administration of dexamethasone diminishes mortality and the severity of brain edema and also significantly decreases brain, liver, and blood levels of triethyltin. It seems likely that the beneficial effect of steroid therapy in this model is at least in part due to enhanced excretion or catabolism of triethyltin bromide.

Original languageEnglish
Pages (from-to)429-437
Number of pages9
JournalExperimental Neurology
Issue number3
StatePublished - Mar 1973


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