Developmentally regulated rearrangement and expression of genes encoding the T cell receptor-T3 complex

A. J. Furley, S. Mizutani, K. Weilbaecher, H. S. Dhaliwal, A. M. Ford, L. C. Chan, H. V. Molgaard, B. Toyonaga, T. Mak, P. van den Elsen, D. Gold, C. Terhorst, M. F. Greaves

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125 Scopus citations

Abstract

Human leukemic cells corresponding to the earliest identifiable stages of intrathymic T cell differentiation lack cell surface expression of the T cell receptor(TCRα/β)-T3 complex but transcribe TCRβ mRNA from either germ-line configuration ( 1 13) or partially (DJ) or fully (VDJ) rearranged ( 12 13) genes. These cells do not produce TCRα mRNA, but do contain T3δ and T3ε{lunate} mRNA and accumulate T3 polypeptides, primarily in the perinuclear envelope. Equivalent normal T cells isolated from thymus have a predominantly germ-line configuration of TCRβ but contain intracellular T3 proteins. T3 gene expression is therefore a very early event in T cell differentiation. TCRα chain production appears to be the limiting maturation-linked event in the transport, assembly, and cell surface membrane insertion of the TCRα β-T3 complex.

Original languageEnglish
Pages (from-to)75-87
Number of pages13
JournalCell
Volume46
Issue number1
DOIs
StatePublished - Jul 4 1986
Externally publishedYes

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    Furley, A. J., Mizutani, S., Weilbaecher, K., Dhaliwal, H. S., Ford, A. M., Chan, L. C., Molgaard, H. V., Toyonaga, B., Mak, T., van den Elsen, P., Gold, D., Terhorst, C., & Greaves, M. F. (1986). Developmentally regulated rearrangement and expression of genes encoding the T cell receptor-T3 complex. Cell, 46(1), 75-87. https://doi.org/10.1016/0092-8674(86)90861-5