Developmental Trajectories of Executive and Verbal Processes in Children with Phenylketonuria

Zoë W. Hawks; Michael J. Strube; Neco X. Johnson; Dorothy K. Grange; Desirée A. White

doi:10.1080/87565641.2018.1438439

Developmental Trajectories of Executive and Verbal Processes in Children with Phenylketonuria

Zoë W. Hawks, Michael J. Strube, Neco X. Johnson, Dorothy K. Grange, Desirée A. White

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Phenylketonuria (PKU) is a hereditary disorder characterized by disrupted phenylalanine metabolism and cognitive impairment. However, the precise nature and developmental trajectory of this cognitive impairment remains unclear. The present study used a verbal fluency task to dissociate executive and verbal processes in children with PKU (n = 23; 7–18 years) and controls (n = 44; 7–19 years). Data were collected at three longitudinal timepoints over a three-year period, and the contributions of age, group, and their interaction to fluency performance were evaluated. Results indicated impairments in executive processes in children with PKU, which were exacerbated by declining metabolic control.

Original language	English
Pages (from-to)	207-218
Number of pages	12
Journal	Developmental Neuropsychology
Volume	43
Issue number	3
DOIs	https://doi.org/10.1080/87565641.2018.1438439
State	Published - Apr 3 2018

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abstract = "Phenylketonuria (PKU) is a hereditary disorder characterized by disrupted phenylalanine metabolism and cognitive impairment. However, the precise nature and developmental trajectory of this cognitive impairment remains unclear. The present study used a verbal fluency task to dissociate executive and verbal processes in children with PKU (n = 23; 7–18 years) and controls (n = 44; 7–19 years). Data were collected at three longitudinal timepoints over a three-year period, and the contributions of age, group, and their interaction to fluency performance were evaluated. Results indicated impairments in executive processes in children with PKU, which were exacerbated by declining metabolic control.",

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AU - Hawks, Zoë W.

AU - Strube, Michael J.

AU - Johnson, Neco X.

AU - Grange, Dorothy K.

AU - White, Desirée A.

PY - 2018/4/3

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N2 - Phenylketonuria (PKU) is a hereditary disorder characterized by disrupted phenylalanine metabolism and cognitive impairment. However, the precise nature and developmental trajectory of this cognitive impairment remains unclear. The present study used a verbal fluency task to dissociate executive and verbal processes in children with PKU (n = 23; 7–18 years) and controls (n = 44; 7–19 years). Data were collected at three longitudinal timepoints over a three-year period, and the contributions of age, group, and their interaction to fluency performance were evaluated. Results indicated impairments in executive processes in children with PKU, which were exacerbated by declining metabolic control.

AB - Phenylketonuria (PKU) is a hereditary disorder characterized by disrupted phenylalanine metabolism and cognitive impairment. However, the precise nature and developmental trajectory of this cognitive impairment remains unclear. The present study used a verbal fluency task to dissociate executive and verbal processes in children with PKU (n = 23; 7–18 years) and controls (n = 44; 7–19 years). Data were collected at three longitudinal timepoints over a three-year period, and the contributions of age, group, and their interaction to fluency performance were evaluated. Results indicated impairments in executive processes in children with PKU, which were exacerbated by declining metabolic control.

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Developmental Trajectories of Executive and Verbal Processes in Children with Phenylketonuria

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