Developmental pathology of congenital kidney and urinary tract anomalies

Research output: Contribution to journalReview articlepeer-review

34 Scopus citations

Abstract

Congenital anomalies of the kidneys or lower urinary tract (CAKUT) are the most common causes of renal failure in children and account for 25% of end-stage renal disease in adults. The spectrum of anomalies includes renal agenesis; hypoplasia; dysplasia; supernumerary, ectopic or fused kidneys; duplication; ureteropelvic junction obstruction; primary megaureter or ureterovesical junction obstruction; vesicoureteral reflux; ureterocele; and posterior urethral valves. CAKUT originates from developmental defects and can occur in isolation or as part of other syndromes. In recent decades, along with better understanding of the pathological features of the human congenital urinary tract defects, researchers using animal models have provided valuable insights into the pathogenesis of these diseases. However, the genetic causes and etiology of many CAKUT cases remain unknown, presenting challenges in finding effective treatment. Here we provide an overview of the critical steps of normal development of the urinary system, followed by a description of the pathological features of major types of CAKUT with respect to developmental mechanisms of their etiology.

Original languageEnglish
Pages (from-to)382-399
Number of pages18
JournalClinical Kidney Journal
Volume12
Issue number3
DOIs
StatePublished - Jun 1 2019

Keywords

  • CAKUT
  • Congenital
  • Development
  • Genetics
  • Kidney
  • Urinary tract

Fingerprint

Dive into the research topics of 'Developmental pathology of congenital kidney and urinary tract anomalies'. Together they form a unique fingerprint.

Cite this